Vitamin C

High-dose vitamin C, administered intravenously, doubled survival rates for late-stage metastatic pancreatic cancer patients from 8 to 16 months in a phase 2 trial. The study found vitamin C generates hydrogen peroxide, which kills cancer cells, and improves chemotherapy tolerance. Researchers suggest further phase 3 trials are needed for widespread clinical use.

ARDS is a complex syndrome with high morbidity and mortality, caused by various clinical conditions. It involves multiple overlapping pathways of injury, inflammation, and coagulation. Despite research, effective therapies are lacking due to ARDS heterogeneity. Personalized mechanical ventilation (MV) strategies and subphenotyping are crucial for better understanding and treatment. Studies highlight the potential of decision support systems (DSS) in refining MV management and improving outcomes. The COVID-19 pandemic underscored the need for individualized yet standardized MV strategies. Optimal PEEP levels must be carefully individualized based on patient cardiovascular function. Closed-loop oxygen control systems show promise in pediatric patients. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is recommended for severe ARDS. ARDS presentation varies significantly across etiological, physiological, and biological dimensions, necessitating a personalized medicine approach.

A user responds to comments on the potential of high-dose IV vitamin C as a cancer therapy, citing existing research and addressing misconceptions about its efficacy and administration.

A physician reflects on a patient's admiration for RFK Jr., discussing the FDA's role in public health, the efficacy and safety of psychedelics, peptides, stem cells, raw milk, hyperbaric therapies, chelation, ivermectin, hydroxychloroquine, vitamins, and nutraceuticals. The article concludes with concerns over RFK Jr.'s potential impact on public health if he were to lead the Department of Health and Human Services, emphasizing the importance of evidence-based medicine and regulatory oversight.

Dr. Sara Szal Gottfried explains that stress responses like anxiety and anger can impact health if chronic, leading to issues like disrupted circadian rhythms, insomnia, and increased risk of heart attack. She suggests managing these emotions through awareness, controlled breathing, and meditation, while also recommending lifestyle changes such as reducing caffeine and alcohol intake.

Winter increases risk of colds, flu, COVID-19, and RSV due to indoor gatherings and cold, dry conditions. Preventive measures include hand washing, avoiding face touching, adequate sleep, and a healthy diet. Essential vitamins and minerals for immune support include Vitamin A, B9, B12, C, D, iron, and zinc, best obtained through varied food sources. Vitamin D deficiency can increase cold susceptibility, while other deficiencies may cause fatigue, hair loss, or mood disorders.

Topical human platelet extract (HPE) and vitamin C show similar improvements in hand photoaging, according to a clinical trial in 'Plastic and Reconstructive Surgery®'. Both treatments reduced brown spots and wrinkles, with HPE considered more reliable due to vitamin C's potential skin issues.

McGuff Pharmaceuticals, Inc. (MPI) received FDA approval for its 86,000-sq.-ft. sterile fill-and-finish facility in Santa Ana, CA, opening new CMO/CDMO opportunities. The facility offers end-to-end drug development and manufacturing services, including formulation, stability, regulatory compliance, and clinical trials. It is designed to produce MPI's NDA and ANDA labeled injectables, contract products, and clinical trial items, including sterile fill-and-finish manufacturing, compounding, and DSCSA-compliant packaging. MPI aims to increase production of its FDA-approved Ascorbic Acid Injection (vitamin C) to meet global demand.