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Vitamin C

Generic Name
Vitamin C
Brand Names
Ascor, Citranatal B-calm Kit, Concept Ob, Ferralet 90, Hematogen, Infuvite, Infuvite Pediatric, Moviprep, Mvc-fluoride, Mvi Pediatric, Natafort, Plenvu, Pregvit, Vitafol-one
Drug Type
Small Molecule
Chemical Formula
C6H8O6
CAS Number
50-81-7
Unique Ingredient Identifier
PQ6CK8PD0R
Background

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Indication

Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

Associated Conditions
Common Cold, Deficiency, Vitamin A, Deficiency, Vitamin D, Fever, Flu caused by Influenza, Folate deficiency, Iron Deficiency (ID), Iron Deficiency Anemia (IDA), Oral bacterial infection, Scurvy, Vitamin C Deficiency, Vitamin Deficiency
Associated Therapies
Nutritional supplementation, Vitamin supplementation
Clinical Trials
Related News

High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

Phase 1
Withdrawn
Conditions
Metastatic Pancreatic Cancer
Interventions
Drug: Ascorbic Acid
Drug: nab paclitaxel
Drug: Cisplatin
Drug: Gemcitabine
First Posted Date
2019-01-09
Last Posted Date
2019-05-31
Lead Sponsor
Piedmont Cancer Institute
Registration Number
NCT03797443
Locations
🇺🇸

Piedmont Cancer Institute, Newnan, Georgia, United States

Effect of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery

Early Phase 1
Conditions
Postoperative Pulmonary Complications
Interventions
Drug: Saline
Drug: Ascorbic Acid
First Posted Date
2018-11-28
Last Posted Date
2018-11-28
Lead Sponsor
Xuzhou Medical University
Target Recruit Count
110
Registration Number
NCT03756727
Locations
🇨🇳

The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac Surgery

Early Phase 1
Completed
Conditions
Vasoplegia
Interventions
Drug: Ascorbic Acid
First Posted Date
2018-11-16
Last Posted Date
2021-03-11
Lead Sponsor
Mayo Clinic
Target Recruit Count
15
Registration Number
NCT03744702
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

Phase 1
Withdrawn
Conditions
Metastatic Pancreatic Cancer
Pancreatic Cancer
Pancreas Cancer
Pancreatic Adenocarcinoma Resectable
Pancreatic Ductal Adenocarcinoma
Pancreatic Metastasis
Interventions
Drug: Ascorbic Acid
Drug: Paclitaxel protein-bound
Drug: Cisplatin
Drug: Gemcitabine
First Posted Date
2018-10-05
Last Posted Date
2019-06-11
Lead Sponsor
Hitendra Patel
Registration Number
NCT03697239
Locations
🇺🇸

UC San Diego Moores Cancer Center, La Jolla, California, United States

Lessening Organ Dysfunction With VITamin C

Phase 3
Completed
Conditions
Sepsis
Vitamin C
Intensive Care Unit
COVID-19
Pandemic
Coronavirus
Interventions
Other: Control
Drug: Vitamin C
First Posted Date
2018-09-21
Last Posted Date
2022-04-04
Lead Sponsor
Université de Sherbrooke
Target Recruit Count
872
Registration Number
NCT03680274
Locations
🇨🇦

Research Center of the CHUS, Sherbrooke, Quebec, Canada

Vitamin C & Thiamine to Treat Sepsis and Septic Shock

Phase 2
Completed
Conditions
Sepsis
Septic Shock
Interventions
Drug: Vitamin C
Drug: Vitamin B1
First Posted Date
2018-07-19
Last Posted Date
2022-09-28
Lead Sponsor
Trinity Health Of New England
Target Recruit Count
120
Registration Number
NCT03592277
Locations
🇺🇸

Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States

A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients

Phase 2
Not yet recruiting
Conditions
Pancreatic Neoplasm
Interventions
Drug: Gemcitabine
Drug: Ascorbate
Radiation: radiation therapy
First Posted Date
2018-05-30
Last Posted Date
2023-02-17
Lead Sponsor
Joseph J. Cullen, MD, FACS
Target Recruit Count
60
Registration Number
NCT03541486
Locations
🇺🇸

The University of Iowa, Iowa City, Iowa, United States

High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas

Phase 1
Completed
Conditions
Soft Tissue Sarcoma
Interventions
Drug: Ascorbate
First Posted Date
2018-04-26
Last Posted Date
2024-06-27
Lead Sponsor
Mohammed Milhem
Target Recruit Count
25
Registration Number
NCT03508726
Locations
🇺🇸

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Vitamin C, Thiamine, and Steroids in Sepsis

Phase 3
Completed
Conditions
Sepsis
Interventions
Drug: Vitamin C Placebo
Drug: Vitamin C
Drug: Thiamine Placebo
Drug: Thiamine
Drug: Hydrocortisone Placebo
Drug: Hydrocortisone
First Posted Date
2018-04-26
Last Posted Date
2021-04-13
Lead Sponsor
Emory University
Target Recruit Count
501
Registration Number
NCT03509350
Locations
🇺🇸

University of Arizona, Tucson, Arizona, United States

🇺🇸

Yale New Haven Hospital, New Haven, Connecticut, United States

🇺🇸

Christiana Care, Newark, Delaware, United States

and more 40 locations

Vitamin C in Post-cardiac Arrest

Phase 2
Active, not recruiting
Conditions
Cardiac Arrest
Interventions
Drug: Vitamin C
Drug: Thiamine
Drug: Placebos
First Posted Date
2018-04-26
Last Posted Date
2024-06-20
Lead Sponsor
Amsterdam UMC, location VUmc
Target Recruit Count
270
Registration Number
NCT03509662
Locations
🇳🇱

VU Medical Center, Amsterdam, Noord-Holland, Netherlands

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