Icotinib

Generic Name
Icotinib
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C22H21N3O4
CAS Number
610798-31-7
Unique Ingredient Identifier
9G6U5L461Q
Background

Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)
...

Indication

Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy.

Associated Conditions
-
Associated Therapies
-

Icotinib With Concurrent Radiotherapy vs. Chemoradiotherapy in Non-small Cell Lung Cancer

First Posted Date
2015-04-02
Last Posted Date
2015-04-02
Lead Sponsor
People's Hospital of Guangxi
Target Recruit Count
80
Registration Number
NCT02407366
Locations
🇨🇳

The people's Hospital of the Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China

High Dose Icotinib in Advanced Non-small Cell Lung Cancer With EGFR 21 Exon Mutation

Phase 4
Conditions
Interventions
First Posted Date
2015-03-31
Last Posted Date
2017-07-28
Lead Sponsor
Betta Pharmaceuticals Co., Ltd.
Target Recruit Count
240
Registration Number
NCT02404675
Locations
🇨🇳

Beijing Chest Hospital, Capital Medical University, Beijing, China

Phase II Study of Icotinib With Concurrent Radiotherapy in Elderly Patients With Esophageal Cancer

First Posted Date
2015-03-02
Last Posted Date
2016-03-22
Lead Sponsor
First People's Hospital of Hangzhou
Target Recruit Count
130
Registration Number
NCT02375581
Locations
🇨🇳

Hangzhou Cancer Hospital, Hangzhou, Zhejiang, China

Evaluation of Icotinib in Metastatic Triple-negative Breast Cancer After Second-line Therapy

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2015-02-12
Last Posted Date
2021-01-29
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
26
Registration Number
NCT02362230
Locations
🇨🇳

Sun Yat-sen University, Cancer Center, Guangzhou, Guangdong, China

A Phase II Study of Icotinib in Treating Patients With Advanced Nasopharyngeal Carcinoma

Phase 2
Conditions
Interventions
First Posted Date
2014-12-31
Last Posted Date
2014-12-31
Lead Sponsor
Betta Pharmaceuticals Co., Ltd.
Target Recruit Count
66
Registration Number
NCT02328261

Icotinib as the Adjunctive Treatment After Surgery in Stage I-IIIB Lung Adenocarcinoma Patients With EGFR Gene Mutation

First Posted Date
2014-11-05
Last Posted Date
2014-11-05
Lead Sponsor
Chinese PLA General Hospital
Target Recruit Count
10
Registration Number
NCT02283424
Locations
🇨🇳

PLA General Hospital, BeiJing, China

Combination of Icotinib and Gemcitabine as First-line Treatment in Pancreatic Cancer

First Posted Date
2014-10-30
Last Posted Date
2015-05-22
Lead Sponsor
Betta Pharmaceuticals Co., Ltd.
Target Recruit Count
24
Registration Number
NCT02278458
Locations
🇨🇳

Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang, China

🇨🇳

Bethune First Hospital of Jilin University, Changchun, Jilin, China

🇨🇳

First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

Study of Chemotherapy Plus Icotinib to Treat EGFR Mutation-positive Non-small-cell Lung Cancer

Phase 2
Conditions
Interventions
First Posted Date
2014-10-22
Last Posted Date
2014-10-22
Lead Sponsor
Nanfang Hospital, Southern Medical University
Target Recruit Count
100
Registration Number
NCT02272127
Locations
🇨🇳

Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China

Icotinib for Completed Resected IB NSCLC With EGFR Mutation

First Posted Date
2014-10-15
Last Posted Date
2021-08-03
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
128
Registration Number
NCT02264210
Locations
🇨🇳

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

Phase II Clinical Study of Intermittent High Dose of Icotinib in Combination With Docetaxel to Treat Lung Cancer

First Posted Date
2014-07-15
Last Posted Date
2014-07-31
Lead Sponsor
Shandong Cancer Hospital and Institute
Target Recruit Count
60
Registration Number
NCT02191059
Locations
🇨🇳

Shandong Cancer Hospital and Institute, Jinan, Shandong, China

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