Metformin
- Generic Name
- Metformin
- Brand Names
- Actoplus Met, Avandamet, Fortamet, Glucophage, Glucovance, Glumetza, Glycon, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze, Komboglyze, Qternmet, Riomet, Segluromet, Synjardy, Trijardy, Velmetia, Xigduo
- Drug Type
- Small Molecule
- Chemical Formula
- C4H11N5
- CAS Number
- 657-24-9
- Unique Ingredient Identifier
- 9100L32L2N
- Background
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.
...
- Indication
Metformin immediate-release formulations
Metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients ≥10 years old with type 2 diabetes mellitus.
Metformin extended-release tablet (XR)
...
- Associated Conditions
- Cardiovascular Mortality, End Stage Renal Disease (ESRD), Hospitalizations, Polycystic Ovarian Syndrome (PCOS), Type 2 Diabetes Mellitus, Decreased estimated glomerular filtration rate
- Associated Therapies
- -
Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2013-01-08
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 20
- Registration Number
- NCT00187681
- Locations
- 🇺🇸
San Francisco General Hospital, San Francsico, California, United States
Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes.
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2017-02-24
- Lead Sponsor
- Novo Nordisk A/S
- Target Recruit Count
- 97
- Registration Number
- NCT00184626
- Locations
- 🇹🇷
Novo Nordisk Investigational Site, Istanbul, Turkey
Comparison of Biphasic Insulin Aspart 70/30, 50/50, and 30/70 in Subjects With Type 2 Diabetes
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2017-01-05
- Lead Sponsor
- Novo Nordisk A/S
- Target Recruit Count
- 603
- Registration Number
- NCT00184574
- Locations
- 🇬🇧
Novo Nordisk Investigational Site, Watford, United Kingdom
Opposing Step-by-step Insulin Reinforcement to Intensified Strategy
- Conditions
- Interventions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2009-09-15
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 811
- Registration Number
- NCT00174642
- Locations
- 🇬🇧
Sanofi-Aventis, Guildford, United Kingdom
Peripheral and Coronary Endothelial Dysfunction In Type 2diabetic Patients- Role of Metformin
- Conditions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2007-10-05
- Lead Sponsor
- Hospices Civils de Lyon
- Target Recruit Count
- 30
- Registration Number
- NCT00169624
- Locations
- 🇫🇷
Laurent SEBBAG, Lyon, France
Metformin in Pregnant PCOS Women
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2019-02-15
- Lead Sponsor
- Norwegian University of Science and Technology
- Target Recruit Count
- 257
- Registration Number
- NCT00159536
- Locations
- 🇳🇴
Central Hospital of Northern Norway, Bodø, Norway
🇳🇴Ringerike Hospital, Hønefoss, Norway
🇳🇴University hospital of Bergen, Bergen, Norway
Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)
- Conditions
- Interventions
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2018-03-21
- Lead Sponsor
- Milton S. Hershey Medical Center
- Target Recruit Count
- 114
- Registration Number
- NCT00151411
- Locations
- 🇺🇸
Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Study of Serum Markers for Cardiovascular Risk in Obese Youth and Impact of Lifestyle and Medication Intervention
- Conditions
- Interventions
- First Posted Date
- 2005-08-31
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Nemours Children's Clinic
- Target Recruit Count
- 66
- Registration Number
- NCT00139477
- Locations
- 🇺🇸
Nemours Children's Clinic, Jacksonville, Florida, United States
Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity
- First Posted Date
- 2005-08-24
- Last Posted Date
- 2022-12-08
- Lead Sponsor
- University Hospital, Ghent
- Target Recruit Count
- 65
- Registration Number
- NCT00134303
- Locations
- 🇧🇪
University Hospital Ghent, Ghent, Belgium
The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance
- Conditions
- First Posted Date
- 2005-08-24
- Last Posted Date
- 2007-12-28
- Lead Sponsor
- University Hospital, Ghent
- Target Recruit Count
- 48
- Registration Number
- NCT00134290
- Locations
- 🇧🇪
University Hospital Ghent, Ghent, Belgium
Drug Development Updates
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