Metformin

To increase longevity and reverse aging, interventions must focus on cell biology. Four therapeutic approaches include a gene expression rheostat, bioelectrome mapping, synaptic regeneration, and senolytics. Life Biosciences targets epigenetic reprogramming and autophagy, while Morphoceuticals maps the bioelectrome for regenerative therapies. Spinogenix develops synaptic regenerative drugs, and Unity Biotechnology creates senolytics to eliminate senescent cells, aiming to treat age-related diseases.

The article reviews diverse methodologies and questionnaires used in human evaluation of LLMs in healthcare, highlighting current practices, challenges, and areas for future research. It discusses the distribution of healthcare applications for LLMs, with Clinical Decision Support (CDS) being the most prevalent (28.1%). The article also explores the use of LLMs in various medical specialties and the evaluation design, including the QUEST principles (Quality of Information, Understanding and Reasoning, Expression Style and Persona, Safety and Harm, Trust and Confidence). It emphasizes the importance of blind assessments to reduce bias and the use of statistical analysis to compare LLM performance against human benchmarks. Specialized frameworks like SERVQUAL and DISCERN are also discussed for comprehensive LLM evaluation.

A Bayesian approach models mixed outcomes within the exponential family, relating expected outcomes with covariates and treatment via canonical parameters. The treatment-control effect contrast is key in clinical trials, with the Bayesian model aiming to estimate treatment effects and interactions on the primary outcome by borrowing information from other correlated outcomes. An individualized treatment decision rule is defined using a treatment benefit index (TBI), predicting optimal treatments for future patients based on pre-treatment characteristics. The model is adaptable to mixed outcome types and was applied to data from a COVID-19 clinical trial, comparing its performance to a univariate model and assessing robustness through sensitivity analyses.

Russia donated $300,000 for an Africa-wide anti-gay conference in Uganda, where lawmakers from across Africa convened to resist Western pressure on gay and reproductive rights. The conference, organized with the help of American religious conservatives, aimed to push for anti-homosexuality laws, including the death penalty for repeated same-sex intimacy. Despite denials, evidence suggests Russia's involvement in funding and advocating for these laws, which have led to increased violence and fear among LGBTQ communities in Uganda and other African countries.

The article discusses the application of a diffusion framework in sequence space for protein generation, detailing the representation of sequences, training process, and inference methods. It emphasizes the use of a continuous representation for categorical sequence data, the implementation of a square root noise schedule, and the incorporation of self-conditioning and iterative guidance during training and inference. The article also covers various protein generation tasks, including unconditional, compositionally biased, charge biased, hydrophobic biased, and DSSP guided protein generation, as well as methods for experimental verification and quality metrics.

Study on primates finds metformin, a popular diabetes drug, may slow organ aging, including the brain, by up to six years. Researchers hope to conduct human trials.

Mitochondrial diseases research highlights implications in neurogenesis, cellular movements, and mitochondrial dysfunction's role in various conditions, including Leigh syndrome and Pearson syndrome, with focus on genetic mutations, therapeutic approaches, and reproductive options for affected families.

Metformin, used for type 2 diabetes, slowed aging in multiple organs, including the brain, in cynomolgus monkeys, with some indicators regressing by six years. Further human trials are needed to explore its potential anti-aging benefits.

Ahmed Best voices a dark Sith Jar Jar Binks in 'LEGO Star Wars: Rebuild the Galaxy,' blending classic and new elements. Co-stars Gaten Matarazzo and Tony Revolori draw inspiration from Luke Skywalker and Anakin Skywalker, respectively, for their characters. The series honors LEGO and Star Wars fandoms, creating a new story with familiar themes.

Pharma industry trends in 2025 include AI/ML in clinical trials, gene therapy, digital therapeutics, and precision medicine, driving efficiency and personalized care.