Overview
Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties .
Background
Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties .
Indication
For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache .
Associated Conditions
- Ankylosing Spondylitis (AS)
- Extra-Articular Rheumatism
- Gout
- Inflammation
- Menstrual Distress (Dysmenorrhea)
- Musculoskeletal Pain
- Myalgia
- Osteoarthritis (OA)
- Pain
- Post Traumatic Pain
- Postoperative pain
- Renal Colic
- Rheumatoid Arthritis
- Spasms
- Spinal pain
- Inflammation localized
- Localized pain
- Mild to moderate pain
Research Report
Dexketoprofen: A Comprehensive Pharmacological and Clinical Review
1. Introduction to Dexketoprofen
1.1. Overview and Background
Dexketoprofen is a well-established non-steroidal anti-inflammatory drug (NSAID) recognized for its analgesic, anti-inflammatory, and antipyretic properties.[1] It holds a specific place in pharmacology as the S(+)-enantiomer of racemic ketoprofen. This stereoisomer is the pharmacologically active component, responsible for the entirety of the therapeutic effects observed with the parent compound, ketoprofen.[1] The development of dexketoprofen as a single enantiomer represents a "chiral switch" from its racemic predecessor, a strategy aimed at optimizing therapeutic action.[4]
The primary clinical application of dexketoprofen is the symptomatic treatment of mild to moderate acute pain across a variety of conditions.[1] Having first received approval in 1994 [1], dexketoprofen is currently available in numerous countries throughout Europe, Asia, and Latin America, where it serves as a common analgesic option.[1] Its utility is particularly noted in situations requiring prompt pain relief.
1.2. Chemical Properties and Formulation
Chemically, dexketoprofen is identified by the International Union of Pure and Applied Chemistry (IUPAC) name (2S)-2-(3-benzoylphenyl)propanoic acid.[1] Its molecular formula is
C16H14O3, corresponding to a molecular weight of approximately 254.28 g/mol.[1] The Chemical Abstracts Service (CAS) registry number for dexketoprofen is 22161-81-5, and it is cataloged in DrugBank under the ID DB09214.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2025/05/02 | N/A | Completed | Enes Celik | ||
2025/04/17 | Phase 4 | Completed | Ali Gur | ||
2025/04/08 | Phase 4 | Completed | ibrahim doğru | ||
2024/08/20 | Phase 4 | Completed | Ankara Etlik City Hospital | ||
2024/08/19 | Phase 4 | Completed | Ismail Tekin | ||
2024/05/08 | Phase 3 | Recruiting | Riadh Boukef | ||
2023/09/29 | Phase 4 | Recruiting | |||
2022/09/07 | Phase 4 | Completed | Yuzuncu Yıl University | ||
2022/03/31 | Not Applicable | Completed | |||
2022/01/04 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
---|---|---|---|---|---|
No FDA approvals found for this drug. |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
---|---|---|---|
No EMA approvals found for this drug. |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
KETESSE TABLET 25 mg | SIN12650P | TABLET, FILM COATED | 25mg | 3/15/2005 | |
SKUDEXA FILM-COATED TABLET 75 MG/25 MG | SIN15394P | TABLET, FILM COATED | 25 mg | 12/13/2017 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
---|---|---|---|---|---|
Dexketoprofen Tablets | 国药准字H20110132 | 化学药品 | 片剂 | 7/28/2021 | |
Dexketoprofen Enteric-coated Tablets | 国药准字H20030967 | 化学药品 | 片剂 | 7/27/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
---|---|---|---|---|---|
No PPB approvals found for this drug. |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
---|---|---|---|---|---|
No TGA approvals found for this drug. |