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Dexketoprofen

Generic Name
Dexketoprofen
Drug Type
Small Molecule
Chemical Formula
C16H14O3
CAS Number
22161-81-5
Unique Ingredient Identifier
6KD9E78X68

Overview

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties .

Background

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties .

Indication

For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache .

Associated Conditions

  • Ankylosing Spondylitis (AS)
  • Extra-Articular Rheumatism
  • Gout
  • Inflammation
  • Menstrual Distress (Dysmenorrhea)
  • Musculoskeletal Pain
  • Myalgia
  • Osteoarthritis (OA)
  • Pain
  • Post Traumatic Pain
  • Postoperative pain
  • Renal Colic
  • Rheumatoid Arthritis
  • Spasms
  • Spinal pain
  • Inflammation localized
  • Localized pain
  • Mild to moderate pain

Research Report

Published: Jun 13, 2025

Dexketoprofen: A Comprehensive Pharmacological and Clinical Review

1. Introduction to Dexketoprofen

1.1. Overview and Background

Dexketoprofen is a well-established non-steroidal anti-inflammatory drug (NSAID) recognized for its analgesic, anti-inflammatory, and antipyretic properties.[1] It holds a specific place in pharmacology as the S(+)-enantiomer of racemic ketoprofen. This stereoisomer is the pharmacologically active component, responsible for the entirety of the therapeutic effects observed with the parent compound, ketoprofen.[1] The development of dexketoprofen as a single enantiomer represents a "chiral switch" from its racemic predecessor, a strategy aimed at optimizing therapeutic action.[4]

The primary clinical application of dexketoprofen is the symptomatic treatment of mild to moderate acute pain across a variety of conditions.[1] Having first received approval in 1994 [1], dexketoprofen is currently available in numerous countries throughout Europe, Asia, and Latin America, where it serves as a common analgesic option.[1] Its utility is particularly noted in situations requiring prompt pain relief.

1.2. Chemical Properties and Formulation

Chemically, dexketoprofen is identified by the International Union of Pure and Applied Chemistry (IUPAC) name (2S)-2-(3-benzoylphenyl)propanoic acid.[1] Its molecular formula is

C16​H14​O3​, corresponding to a molecular weight of approximately 254.28 g/mol.[1] The Chemical Abstracts Service (CAS) registry number for dexketoprofen is 22161-81-5, and it is cataloged in DrugBank under the ID DB09214.

Continue reading the full research report

FDA Drug Approvals

Approved Product
Manufacturer
NDC Code
Route
Strength
Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product
Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product
Manufacturer
Approval Number
Dosage Form
Strength
Approval Date
KETESSE TABLET 25 mg
SIN12650P
TABLET, FILM COATED
25mg
3/15/2005
SKUDEXA FILM-COATED TABLET 75 MG/25 MG
SIN15394P
TABLET, FILM COATED
25 mg
12/13/2017

NMPA Drug Approvals

Approved Product
Company
Approval Number
Drug Type
Dosage Form
Approval Date
Dexketoprofen Tablets
国药准字H20110132
化学药品
片剂
7/28/2021
Dexketoprofen Enteric-coated Tablets
国药准字H20030967
化学药品
片剂
7/27/2020

PPB Drug Approvals

Approved Product
Registration No.
Company
Licence No.
Strength
Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product
ARTG ID
Sponsor
Registration Type
Status
Registration Date
No TGA approvals found for this drug.
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