Dextromethorphan

Generic Name: Dextromethorphan

Brand Names: Auvelity, Benylin DM, Bromfed DM, Broncotron, Cepacol Sore Throat Plus Cough, Cheracol D, Children's Nyquil Cold and Cough, Chloraseptic Sore Throat + Cough, Coricidin Hbp Chest Congestion, Coricidin Hbp Cough and Cold, Creomulsion, DM, Dayquil Cough, Delsym, Delsym Cough Plus Chest Congestion DM, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Despec Reformulated Jun 2008, Diabetic Tussin DM, Dimetapp Long Acting Cough Plus Cold, Diphen, G-zyncof, Mucinex Children's Cough, Mucinex Cough, Mucinex DM, Nuedexta, Nyquil Cough, Pediacare Children's Cough and Congestion, Promethazine DM, Robafen Cough, Robafen DM, Robitussin 12 Hour Cough Relief, Robitussin Cough & Congestion, Robitussin Maximum Strength Cough Plus Chest Congestion DM, Robitussin Nighttime Cough DM, Robitussin Pediatric Cough & Cold LA, Robitussin Pediatric Cough Suppressant, Safetussin DM, Safetussin PM, Scot-tussin DM, Scot-tussin Diabetic CF, Scot-tussin Sugar Free DM, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Tusnel Diabetic

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₅NO

CAS Number: 125-71-3

Unique Ingredient Identifier: 7355X3ROTS

Background: Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors.

Dextromethorphan was granted FDA approval before 3 December 1957.

Indication: Dextromethorphan is indicated in combination with brompheniramine and pseudoephedrine in the treatment of coughs and upper respiratory symptoms associated with allergies or the common cold. Dextromethorphan is also used in combination with guaifenesin as an over-the-counter product to relieve a cough. Dextromethorphan in combination with quinidine is indicated in the treatment of pseudobulbar affect.

Associated Conditions: Allergic cough, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Major Depressive Disorder (MDD), Nasal Congestion, Pseudobulbar Affect (PBA), Rhinorrhoea, Sneezing, Cold or flu syndrome, Upper respiratory symptoms, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis

Clinical Trials

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir

Phase 1

Completed

Conditions: Malaria

Interventions: Drug: Midazolam
Drug: Rosuvastatin
Drug: Repaglinide
Drug: Dolutegravir
Drug: Dextromethorphan
Drug: Metformin
Drug: Ganaplacide
Combination Product: Lumefantrine

First Posted Date: 2022-02-11

Last Posted Date: 2022-11-04

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 48

Registration Number: NCT05236530

Locations: 🇬🇧
Novartis Investigative Site, Belfast, Northern Ireland, United Kingdom

Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder

Phase 4

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Selective Serotonin Reuptake Inhibitors
Drug: Placebo
Drug: Dextromethorphan

First Posted Date: 2022-01-06

Last Posted Date: 2023-12-22

Lead Sponsor: All India Institute of Medical Sciences, Bhubaneswar

Target Recruit Count: 60

Registration Number: NCT05181527

Locations: 🇮🇳
All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India

Psilocybin-facilitated Treatment for Chronic Pain

Early Phase 1

Recruiting

Conditions: Fibromyalgia, Primary

Interventions: Drug: Psilocybin
Drug: Dextromethorphan

First Posted Date: 2021-10-06

Last Posted Date: 2024-10-24

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 30

Registration Number: NCT05068791

Locations: 🇺🇸
UAB Beacon Tower, Birmingham, Alabama, United States

Dextromethorphan Added on for Children With Chronic Irritability

Phase 4

Conditions: Irritable Mood

Interventions: Drug: Dextromethorphan
Other: placebo

First Posted Date: 2021-09-14

Last Posted Date: 2023-04-12

Lead Sponsor: Tri-Service General Hospital

Target Recruit Count: 120

Registration Number: NCT05043805

Locations: 🇨🇳
Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity

Early Phase 1

Recruiting

Conditions: Low Intensity Focussed Ultrasound

Interventions: Drug: Carbamazepine
Drug: Lorazepam
Drug: Dextromethorphan
Drug: Nimodipine
Drug: Placebo

First Posted Date: 2021-06-11

Last Posted Date: 2022-05-25

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 20

Registration Number: NCT04923659

Locations: 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada

Study of Dextromethorphan in OCD and Related Disorders

Phase 2

Recruiting

Conditions: Body Dysmorphic Disorders
Somatic Symptom Disorder
Obsessive-Compulsive Disorder
Illness Anxiety Disorder

Interventions: Drug: Fluoxetine
Drug: Dextromethorphan

First Posted Date: 2021-05-24

Last Posted Date: 2024-04-26

Lead Sponsor: Stanford University

Target Recruit Count: 60

Registration Number: NCT04899687

Locations: 🇺🇸
Stanford University, Stanford, California, United States

PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates

Phase 1

Completed

Conditions: Advanced Solid Tumor

Interventions: Drug: Sitravatinib
Drug: Warfarin
Drug: Nivolumab
Drug: Dextromethorphan
Drug: Midazolam
Drug: Digoxin
Drug: Rosuvastatin

First Posted Date: 2021-05-14

Last Posted Date: 2024-05-08

Lead Sponsor: Mirati Therapeutics Inc.

Target Recruit Count: 40

Registration Number: NCT04887194

Locations: 🇺🇸
Goshen Health, Goshen, Indiana, United States
🇺🇸
MultiCare Health System, Tacoma, Washington, United States
🇺🇸
NEXT Oncology, Fairfax, Virginia, United States

Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction

Phase 2

Conditions: Pharmacotherapy
Amphetamine Addiction

Interventions: Drug: Placebo
Drug: Dextromethorphan and memantine
Drug: Dextromethorphan
Drug: Memantine

First Posted Date: 2020-12-29

Last Posted Date: 2020-12-29

Lead Sponsor: National Cheng-Kung University Hospital

Target Recruit Count: 120

Registration Number: NCT04687566

Locations: 🇨🇳
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan