Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Do Flavors Increase the Addiction Potential of Nicotine?

Phase 2

Completed

Conditions: Nicotine Dependence

Interventions: Drug: Nicotine
Device: JUUL e-cigarette

First Posted Date: 2021-01-06

Last Posted Date: 2022-03-22

Lead Sponsor: University of Vermont

Target Recruit Count: 19

Registration Number: NCT04696380

Locations: 🇺🇸
University of Vermont, Burlington, Vermont, United States

Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients

Phase 3

Completed

Conditions: SARS-COV2

Interventions: Drug: Nicotine 7 mg/ 24h Transdermal Patch - 24 Hour
Drug: Placebo of NICOTINE Transdermal patch

First Posted Date: 2020-10-29

Last Posted Date: 2022-02-11

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 32

Registration Number: NCT04608201

Locations: 🇫🇷
Hospital Pitié-Salpêtrière - AP-HP, Paris, France

Efficacy of Nicotine in Preventing COVID-19 Infection

Phase 3

Conditions: Covid19
SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere

Interventions: Drug: Nicotine patch
Drug: Placebo patch

First Posted Date: 2020-10-12

Last Posted Date: 2021-02-17

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 1633

Registration Number: NCT04583410

Locations: 🇫🇷
Centre Hospitalier Gonesse, Gonesse, France
🇫🇷
Hôpital Pitié Salpêtrière - Service de Médecine Interne, Paris, France
🇫🇷
Hôpital Sainte-Anne, Paris, France

and more 1 locations

Nicotine's Potential Abuse With Menthol

Early Phase 1

Completed

Conditions: Nicotine Dependence

Interventions: Drug: Nicotine

First Posted Date: 2020-09-01

Last Posted Date: 2024-08-26

Lead Sponsor: Yale University

Target Recruit Count: 16

Registration Number: NCT04535362

Locations: 🇺🇸
Department of Veterans Affairs Hospital, West Haven, Connecticut, United States

Effects of Menthol in E-cigarettes on Smoking Behaviors

Phase 1

Completed

Conditions: Nicotine Dependence

Interventions: Drug: Nicotine

First Posted Date: 2020-08-20

Last Posted Date: 2023-12-15

Lead Sponsor: Yale University

Target Recruit Count: 10

Registration Number: NCT04521647

Locations: 🇺🇸
Connecticut Mental Health Center, New Haven, Connecticut, United States

A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV

Phase 4

Active, not recruiting

Conditions: Tobacco Use Cessation

Interventions: Drug: Nicotine patch, nicotine gum, nicotine nasal spray, nicotine inhaler
Drug: Varenicline or bupropion
Behavioral: Contingency Management

First Posted Date: 2020-07-28

Last Posted Date: 2025-01-09

Lead Sponsor: Yale University

Target Recruit Count: 320

Registration Number: NCT04490057

Locations: 🇺🇸
SUNY Downstate STAR Clinic, Brooklyn, New York, United States
🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States
🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States

and more 1 locations

Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

Not Applicable

Active, not recruiting

Conditions: Nicotine Dependence

Interventions: Drug: Nicotine
Device: Vaporizer Device

First Posted Date: 2020-01-18

Last Posted Date: 2024-07-15

Lead Sponsor: Roswell Park Cancer Institute

Target Recruit Count: 20

Registration Number: NCT04231539

Locations: 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States

Behavioral Pharmacology of Cannabis and Nicotine

Phase 1

Completed

Conditions: Cannabis
Nicotine

Interventions: Drug: Cannabis
Drug: Nicotine

First Posted Date: 2019-10-11

Last Posted Date: 2024-04-17

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 26

Registration Number: NCT04124432

Locations: 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States

Smoking Reduction Intervention for Smoking Parents of Paediatric Patients in Hong Kong

Phase 4

Completed

Conditions: Smoking, Tobacco

Interventions: Drug: Nicotine patch

First Posted Date: 2019-03-19

Last Posted Date: 2021-03-29

Lead Sponsor: Chinese University of Hong Kong

Target Recruit Count: 210

Registration Number: NCT03879889

Locations: 🇭🇰
Prince of Wales Hospital, Hong Kong, Hong Kong

Effects of E-cigarette Flavors on Youth TCORS 2.0

Phase 1

Completed

Conditions: Nicotine Use Disorder

Interventions: Drug: Flavoring Agents
Drug: Nicotine

First Posted Date: 2018-08-17

Last Posted Date: 2024-08-09

Lead Sponsor: Yale University

Target Recruit Count: 42

Registration Number: NCT03634839

Locations: 🇺🇸
CMHC, Substance Abuse Center, New Haven, Connecticut, United States

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