Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Sensitivity to Intravenous Nicotine: Genetic Moderators

Phase 1

Completed

Conditions: Nicotine Dependence

Interventions: Drug: saline
Drug: Nicotine

First Posted Date: 2009-09-01

Last Posted Date: 2017-04-19

Lead Sponsor: Yale University

Target Recruit Count: 213

Registration Number: NCT00969137

Locations: 🇺🇸
Department of Veterans Affairs, West Haven, Connecticut, United States

Study of NP002 in Subjects With Idiopathic Parkinson's Disease to Treat Dyskinesias Due to Levodopa Therapy

Phase 1

Completed

Conditions: Parkinson's Disease

Interventions: Other: placebo comparator
Drug: nicotine

First Posted Date: 2009-08-13

Last Posted Date: 2011-10-05

Lead Sponsor: Neuraltus Pharmaceuticals, Inc.

Target Recruit Count: 65

Registration Number: NCT00957918

Locations: 🇺🇸
Strurers Parkinson's Center, Golden Valley, Minnesota, United States
🇺🇸
Barrow Neurology Clinics at St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States
🇺🇸
Keck/USC School of Medicine -Department of Neurology, Los Angelis, California, United States

and more 9 locations

Efficacy and Safety Following Use of a Novel Nicotine Replacement Therapy

Not Applicable

Completed

Conditions: Smoking Cessation

Interventions: Drug: Placebo
Drug: Nicotine

First Posted Date: 2009-04-16

Last Posted Date: 2012-07-02

Lead Sponsor: McNeil AB

Target Recruit Count: 479

Registration Number: NCT00882375

Locations: 🇩🇰
Gentofte University Hospital, Hellerup, Denmark
🇩🇪
University of Heidelberg, Mannheim, Germany
🇩🇪
University Hospital of Tuebingen, Tuebingen, Germany

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

Not Applicable

Completed

Conditions: Bladder Cancer
Cervical Cancer
Esophageal Cancer
Gastric Cancer
Head and Neck Cancer
Kidney Cancer
Leukemia
Liver Cancer
Lung Cancer
Pancreatic Cancer

Interventions: Other: placebo
Drug: varenicline
Drug: nicotine

First Posted Date: 2008-11-13

Last Posted Date: 2018-06-06

Lead Sponsor: Butler Hospital

Target Recruit Count: 315

Registration Number: NCT00790569

Locations: 🇺🇸
Rhode Island Hospital Comprehensive Cancer Center, Providence, Rhode Island, United States

Clinical Study of Smoke-Break Liquid Cigarettes

Phase 2

Completed

Conditions: Smoking

Interventions: Drug: Nicotine
Device: Smoke-Break nicotine delivery device

First Posted Date: 2008-07-15

Last Posted Date: 2014-11-19

Lead Sponsor: Smoke-Break, Inc.

Target Recruit Count: 52

Registration Number: NCT00715871

Locations: 🇺🇸
Tommy G. Thompson Youth Center, West Allis, Wisconsin, United States

Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects

Phase 1

Completed

Conditions: Healthy Subjects

Interventions: Drug: Ketamine and Nicotine
Drug: Placebo
Drug: Nicotine
Drug: Ketamine

First Posted Date: 2008-06-04

Last Posted Date: 2012-05-09

Lead Sponsor: Yale University

Target Recruit Count: 30

Registration Number: NCT00690170

Locations: 🇺🇸
Veterans Administration Hospital, West Haven, Connecticut, United States

Oral Tolerability Of Two Nicotine Dosage Forms

Phase 1

Completed

Conditions: Healthy Volunteer Smokers

Interventions: Drug: Nicotine

First Posted Date: 2008-05-22

Last Posted Date: 2013-03-01

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 200

Registration Number: NCT00682461

Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms

Phase 4

Completed

Conditions: Smoking

Interventions: Drug: Nicotine
Drug: Placebo

First Posted Date: 2008-04-14

Last Posted Date: 2015-03-02

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 23

Registration Number: NCT00657020

Nicotine Patch Pretreatment for Smoking Cessation in PTSD

Early Phase 1

Completed

Conditions: Tobacco Use Disorder
Stress Disorders, Posttraumatic

Interventions: Behavioral: Cognitive Behavioral Therapy for Smoking Cessation
Drug: Nicotine
Drug: Placebo patch
Drug: Bupropion Sustained Release (SR)

First Posted Date: 2008-02-28

Last Posted Date: 2014-11-20

Lead Sponsor: US Department of Veterans Affairs

Target Recruit Count: 87

Registration Number: NCT00625131

Locations: 🇺🇸
VA Medical Center, Durham, Durham, North Carolina, United States

Effects of Smoking on Opioid Receptor Binding: A PET Study

Phase 1

Completed

Conditions: Substance-related Discorder

First Posted Date: 2008-02-20

Last Posted Date: 2018-04-05

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Target Recruit Count: 26

Registration Number: NCT00618631

Locations: 🇺🇸
Johns Hopkins Medical Institute, Baltimore, Maryland, United States
🇺🇸
National Institute on Drug Abuse, Baltimore, Maryland, United States

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