Overview
GC-376 is a 3C-like protease (3CL or M) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells. The compound is known as a direct acting antiviral (DAA) for coronaviruses, and was initially developed using structure-guided design to combat MERS-Cov infections. In addition, GC-376 displays potent activity against various coronaviruses such as feline, ferret, and mink M coronavirus. A prodrug of GC-373, GC-376 has recently been used to test inhibition of SARS-Cov-2 M in vitro, and results show potent inhibition of this target. These results suggest that GC-376, and its metabolites may have therapeutic potential for Covid-19.
Background
GC-376 is a 3C-like protease (3CL or M) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells. The compound is known as a direct acting antiviral (DAA) for coronaviruses, and was initially developed using structure-guided design to combat MERS-Cov infections. In addition, GC-376 displays potent activity against various coronaviruses such as feline, ferret, and mink M coronavirus. A prodrug of GC-373, GC-376 has recently been used to test inhibition of SARS-Cov-2 M in vitro, and results show potent inhibition of this target. These results suggest that GC-376, and its metabolites may have therapeutic potential for Covid-19.
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Clinical Trials
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No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
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EMA Drug Approvals
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HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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TGA Drug Approvals
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