A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to ce...
For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
The Second affiliated Hosptial of Chongqing medical University, Chongqing, China
Karmanos Cancer Center (Wayne State University), Detroit, Michigan, United States
University of Virginia Health System, Charlottesville, Virginia, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Beijing Cancer Hospital, Beijing, China
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Peking University Institute of Hematology, Beijing, Beijing, China
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Henry Ford Health System, Detroit, Michigan, United States
Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Chongqing University Cancer Hospital, Chongqing, Chongqing, China
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