Ixazomib
- Generic Name
- Ixazomib
- Brand Names
- Ninlaro
- Drug Type
- Small Molecule
- Chemical Formula
- C14H19BCl2N2O4
- CAS Number
- 1072833-77-2
- Unique Ingredient Identifier
- 71050168A2
Overview
Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.
Background
Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.
Indication
Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.
Associated Conditions
- Multiple Myeloma (MM)
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2019/05/08 | Phase 3 | Completed | |||
2019/04/04 | N/A | UNKNOWN | Multinational Center for Quality of Life Research, Russia | ||
2019/03/25 | Phase 1 | Withdrawn | |||
2019/03/19 | Phase 1 | Withdrawn | |||
2019/02/27 | Phase 1 | Withdrawn | |||
2019/01/25 | Phase 1 | Active, not recruiting | Therapeutic Advances in Childhood Leukemia Consortium | ||
2018/12/21 | Phase 1 | Recruiting | |||
2018/12/10 | Phase 1 | Completed | |||
2018/12/04 | Phase 2 | Active, not recruiting | |||
2018/11/21 | Phase 3 | Completed |
FDA Approved Products
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