Porfimer Sodium
- Generic Name
- Porfimer Sodium
- Brand Names
- Photofrin
- Drug Type
- Small Molecule
- Chemical Formula
- -
- CAS Number
- 87806-31-3
- Unique Ingredient Identifier
- Y3834SIK5F
- Background
The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
- Indication
临床上用于对不能用手术及其他根治疗法的肺、子宫颈癌或需非手术治疗的患者，在内镜下能观察到病灶的全貌、可能进行激光照射的下列疾病：早期肺癌（0期或Ⅰ期）、浅表性食管癌、浅表性早期胃癌、宫颈癌初期及发育异常。
- Associated Conditions
- Barrett's Esophagus, Esophageal Cancer, Completely obstructive Non-small cell lung cancer, Microinvasive endobrachial Non-small cell lung cancer, Partially obstructive Non-small cell lung cancer
- Associated Therapies
- -
Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease
- First Posted Date
- 2021-04-08
- Last Posted Date
- 2024-06-04
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 16
- Registration Number
- NCT04836429
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Novel Light Delivery Methods for Lung Cancer Photodynamic Therapy - A Pilot Study
- First Posted Date
- 2021-02-15
- Last Posted Date
- 2021-02-15
- Lead Sponsor
- Taoyuan General Hospital
- Target Recruit Count
- 3
- Registration Number
- NCT04753918
Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer
- Conditions
- Interventions
- First Posted Date
- 2018-11-08
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 19
- Registration Number
- NCT03735095
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer
- First Posted Date
- 2018-11-01
- Last Posted Date
- 2024-11-15
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 5
- Registration Number
- NCT03727061
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-09-19
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 9
- Registration Number
- NCT03678350
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Safety of PDT-Photofrin® Prior to Lung Surgery
- Conditions
- Interventions
- First Posted Date
- 2017-11-17
- Last Posted Date
- 2020-01-13
- Lead Sponsor
- Concordia Laboratories Inc.
- Target Recruit Count
- 10
- Registration Number
- NCT03344861
- Locations
- 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States
🇺🇸Cedars-Sinai Medical Center, Los Angeles, California, United States
🇺🇸University of Colorado, Denver, Colorado, United States
Feasibility Study of Using Navigational Bronchoscopy to Perform PDT-Photofrin® in Unresectable Peripheral Lung Cancer
- Conditions
- Interventions
- First Posted Date
- 2016-09-27
- Last Posted Date
- 2020-03-04
- Lead Sponsor
- Concordia Laboratories Inc.
- Target Recruit Count
- 5
- Registration Number
- NCT02916745
- Locations
- 🇺🇸
University of Florida, Gainesville, Florida, United States
🇺🇸Southeastern Regional Medical Center, Atlanta, Georgia, United States
🇺🇸Providence Medical Research Center, Spokane, Washington, United States
Photodynamic Therapy During Surgery in Treating Patients With Pleural Malignancy
Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer
- Conditions
- Recurrent Lip and Oral Cavity Squamous Cell CarcinomaRecurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult PrimaryRecurrent Laryngeal Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell CarcinomaRecurrent Oral Cavity Verrucous CarcinomaRecurrent Laryngeal Verrucous CarcinomaTongue Carcinoma
- Interventions
- First Posted Date
- 2014-02-21
- Last Posted Date
- 2017-10-11
- Lead Sponsor
- Roswell Park Cancer Institute
- Target Recruit Count
- 3
- Registration Number
- NCT02068157
- Locations
- 🇺🇸
Roswell Park Cancer Institute, Buffalo, New York, United States
Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer
- First Posted Date
- 2013-01-17
- Last Posted Date
- 2018-12-13
- Lead Sponsor
- John DeWitt
- Target Recruit Count
- 12
- Registration Number
- NCT01770132
- Locations
- 🇺🇸
IU Simon Cancer Center, Indianapolis, Indiana, United States
Drug Development Updates
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