Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
Minocycline was granted FDA approval on 30 June 1971.
- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumoniae, Chlamydia trachomatis, Chlamydophila psittaci, Chlamydia trachomatis, Ureaplasma urealyticum, Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Vibrio cholerae, Campylobacter fetus, Brucella species, Bartonella bacilliformis, Klebsiella granulomatis, Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species, Haemophilus influenzae, and Kelbsiella species.
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
- Associated Therapies
- -
Minocycline Augmentation in Schizophrenia
- First Posted Date
- 2012-03-23
- Last Posted Date
- 2012-03-23
- Target Recruit Count
- 120
- Registration Number
- NCT01561742
- Locations
- 🇺🇸
Harris County Psychiatric Center, Houston, Texas, United States
Minocycline in the Treatment of Angelman Syndrome
- First Posted Date
- 2012-02-13
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- University of South Florida
- Target Recruit Count
- 25
- Registration Number
- NCT01531582
- Locations
- 🇺🇸
Univeristy of South Florida, Tampa, Florida, United States
Minocycline for Bipolar Depression
- First Posted Date
- 2012-01-23
- Last Posted Date
- 2017-01-30
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 20
- Registration Number
- NCT01514422
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia
- First Posted Date
- 2011-12-16
- Last Posted Date
- 2011-12-16
- Lead Sponsor
- Central South University
- Target Recruit Count
- 78
- Registration Number
- NCT01493622
- Locations
- 🇨🇳
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China
Minocycline to Treat Branch Retinal Vein Occlusion
- Conditions
- Interventions
- First Posted Date
- 2011-11-10
- Last Posted Date
- 2022-01-26
- Lead Sponsor
- National Eye Institute (NEI)
- Target Recruit Count
- 9
- Registration Number
- NCT01468831
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
🇬🇧Bristol Eye Hospital, Bristol, United Kingdom
Minocycline to Treat Central Retinal Vein Occlusion
- Conditions
- Interventions
- First Posted Date
- 2011-11-10
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- National Eye Institute (NEI)
- Target Recruit Count
- 6
- Registration Number
- NCT01468844
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
🇬🇧Bristol Eye Hospital, Bristol, United Kingdom
Minocycline in Patients With Alzheimer's Disease
- Conditions
- Interventions
- First Posted Date
- 2011-11-01
- Last Posted Date
- 2014-09-25
- Lead Sponsor
- Huntington Medical Research Institutes
- Target Recruit Count
- 13
- Registration Number
- NCT01463384
- Locations
- 🇺🇸
Huntington Medical Research Institutes, Pasadena, California, United States
Adjunctive Minocycline in Clozapine Treated Schizophrenia Patients
- First Posted Date
- 2011-09-13
- Last Posted Date
- 2019-08-28
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 52
- Registration Number
- NCT01433055
- Locations
- 🇺🇸
Maryland Psychiatric Research Center, Catonsville, Maryland, United States
Minocycline and Aspirin in the Treatment of Bipolar Depression
- Conditions
- Interventions
- First Posted Date
- 2011-09-07
- Last Posted Date
- 2018-01-11
- Lead Sponsor
- Laureate Institute for Brain Research, Inc.
- Target Recruit Count
- 99
- Registration Number
- NCT01429272
- Locations
- 🇺🇸
Laureate Institute for Brain Research, Tulsa, Oklahoma, United States
🇺🇸University of Oklahoma Department of Psychiatry, Tulsa, Oklahoma, United States
🇺🇸University of Kansas Medical Center Research Institute, Wichita, Kansas, United States
Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2011-08-23
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- Baystate Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT01422148
- Locations
- 🇺🇸
Abdallah Alameddine, Melrose, Massachusetts, United States
Drug Development Updates
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