Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
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- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumo...
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
- Associated Therapies
- -
Use of Minocycline in Intracerebral Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2017-02-02
- Last Posted Date
- 2017-02-02
- Lead Sponsor
- University of Tennessee
- Target Recruit Count
- 20
- Registration Number
- NCT03040128
Neurophysiological and Acute Pharmacological Studies in FXS Patients
- Conditions
- Interventions
- First Posted Date
- 2016-12-20
- Last Posted Date
- 2021-11-26
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 29
- Registration Number
- NCT02998151
- Locations
- 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Minocycline and Tobacco Craving in Smokers With Schizophrenia
- First Posted Date
- 2016-11-18
- Last Posted Date
- 2022-01-06
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 32
- Registration Number
- NCT02968602
- Locations
- 🇺🇸
Maryland Psyciatric Research Center, Catonsville, Maryland, United States
Open Label Photo-Documentation Study Of BPX-01 Minocycline Gel
- First Posted Date
- 2016-10-27
- Last Posted Date
- 2022-07-26
- Lead Sponsor
- BioPharmX, Inc.
- Target Recruit Count
- 20
- Registration Number
- NCT02946788
- Locations
- 🇺🇸
Study Center, Las Vegas, Nevada, United States
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
- Conditions
- Interventions
- First Posted Date
- 2016-10-10
- Last Posted Date
- 2020-01-28
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 750
- Registration Number
- NCT02928692
- Locations
- 🇨🇳
Shanghai Pudong New Area Dongming Community Health Care Center, Shanghai, China
🇨🇳Scales, Shanghai, Shanghai, China
🇨🇳Shanghai Pudong Hospital, Shanghai, China
The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms
- Conditions
- Interventions
- First Posted Date
- 2016-10-10
- Last Posted Date
- 2019-04-18
- Lead Sponsor
- University of Manchester
- Target Recruit Count
- 207
- Registration Number
- NCT02928965
Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia
- First Posted Date
- 2016-09-20
- Last Posted Date
- 2016-09-20
- Lead Sponsor
- Beer Yaakov - Ness Ziona Mental Health Center
- Target Recruit Count
- 40
- Registration Number
- NCT02907437
- Locations
- 🇮🇱
Bees Yaakov and Ness Ziona Mental Health Center, Beer Yaakov, Israel
A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma
- First Posted Date
- 2016-05-12
- Last Posted Date
- 2021-10-05
- Lead Sponsor
- University of Ulm
- Target Recruit Count
- 10
- Registration Number
- NCT02770378
- Locations
- 🇩🇪
University of Ulm School of Medicine, Ulm, Baden-Württemberg, Germany
Depression, Obesity and Inflammatory Markers
- First Posted Date
- 2016-05-06
- Last Posted Date
- 2020-07-01
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 21
- Registration Number
- NCT02765100
- Locations
- 🇺🇸
Weill Cornell Medical College, New York, New York, United States
A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression
- Conditions
- Interventions
- First Posted Date
- 2016-03-25
- Last Posted Date
- 2022-04-21
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT02719392
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Drug Development Updates
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