Minocycline
- Generic Name
- Minocycline
- Brand Names
- Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
- Drug Type
- Small Molecule
- Chemical Formula
- C23H27N3O7
- CAS Number
- 10118-90-8
- Unique Ingredient Identifier
- FYY3R43WGO
- Background
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
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- Indication
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumo...
- Associated Conditions
- Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
- Associated Therapies
- -
Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression
- Conditions
- Interventions
- First Posted Date
- 2016-03-09
- Last Posted Date
- 2019-08-05
- Lead Sponsor
- Pakistan Institute of Living and Learning
- Target Recruit Count
- 265
- Registration Number
- NCT02703363
- Locations
- 🇵🇰
Karwan-e-Hayat, Karachi, Sindh, Pakistan
🇵🇰Abbasi Shaheed Hospital, Karachi, Sindh, Pakistan
🇵🇰Dow University of Health Sciences, Karachi, Sindh, Pakistan
Administration of Oral Extended Release Minocycline for Assessment of Skin and Plasma Concentrations of Minocycline
- First Posted Date
- 2016-03-01
- Last Posted Date
- 2017-09-14
- Lead Sponsor
- BioPharmX, Inc.
- Target Recruit Count
- 12
- Registration Number
- NCT02695446
- Locations
- 🇺🇸
KGL Skin Study Center, Broomall, Pennsylvania, United States
Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States
- Conditions
- Interventions
- First Posted Date
- 2015-10-06
- Last Posted Date
- 2019-08-05
- Lead Sponsor
- Pakistan Institute of Living and Learning
- Target Recruit Count
- 326
- Registration Number
- NCT02569307
- Locations
- 🇵🇰
Civil hospital Karachi, Karachi, Sindh, Pakistan
🇵🇰Karwn e Hayat, Karachi, Sindh, Pakistan
🇵🇰Abasi Shaheed Hospital, Karachi, Sindh, Pakistan
Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration
- First Posted Date
- 2015-10-01
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- National Eye Institute (NEI)
- Target Recruit Count
- 37
- Registration Number
- NCT02564978
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence
- First Posted Date
- 2015-09-04
- Last Posted Date
- 2015-09-04
- Lead Sponsor
- Universiti Sains Malaysia
- Target Recruit Count
- 40
- Registration Number
- NCT02541500
- Locations
- 🇲🇾
University Science Malaysia, Kota Bharu, Kelantan, Malaysia
PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
- Conditions
- Interventions
- First Posted Date
- 2015-09-04
- Last Posted Date
- 2019-04-18
- Lead Sponsor
- University of South Carolina
- Target Recruit Count
- 400
- Registration Number
- NCT02541032
- Locations
- 🇺🇸
University of South Carolina School of Medicine Department of Neurology, Columbia, South Carolina, United States
🇺🇸University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2015-08-26
- Last Posted Date
- 2022-04-29
- Lead Sponsor
- Pakistan Institute of Living and Learning
- Target Recruit Count
- 60
- Registration Number
- NCT02533232
- Locations
- 🇵🇰
Abasi Shaheed Hospital, Karachi, Sindh, Pakistan
🇵🇰Karwn e Hayat, Karachi, Sindh, Pakistan
🇵🇰Institute of Behavioral Sciences, Karachi, Sindh, Pakistan
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54175446 in Healthy Male Participants
- Conditions
- Interventions
- First Posted Date
- 2015-08-05
- Last Posted Date
- 2016-06-06
- Lead Sponsor
- Janssen-Cilag International NV
- Target Recruit Count
- 76
- Registration Number
- NCT02515955
Adjunct Minocyline in Treatment-resistant Depression
- First Posted Date
- 2015-05-29
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 168
- Registration Number
- NCT02456948
- Locations
- 🇩🇪
Department of Psychiatry, University Medical Center Göttingen, Göttingen, Lower Saxony, Germany
🇩🇪Department of Psychiatry, LMU Munich, Munich, Bavaria, Germany
🇩🇪Max Planck Institute of Psychiatry, Munich, Bavaria, Germany
Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder
- Conditions
- Interventions
- First Posted Date
- 2015-02-13
- Last Posted Date
- 2019-05-23
- Lead Sponsor
- Centre for Addiction and Mental Health
- Target Recruit Count
- 115
- Registration Number
- NCT02362529
- Locations
- 🇨🇦
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Drug Development Updates
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