Minocycline

Generic Name
Minocycline
Brand Names
Amzeeq, Arestin, Dynacin, Minocin, Minolira, Solodyn, Ximino, Zilxi
Drug Type
Small Molecule
Chemical Formula
C23H27N3O7
CAS Number
10118-90-8
Unique Ingredient Identifier
FYY3R43WGO
Background

Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.

Minocycline was granted FDA approval on 30 June 1971.

Indication

Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris. Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis. Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms. These include rickettsiae, Mycoplasma pneumoniae, Chlamydia trachomatis, Chlamydophila psittaci, Chlamydia trachomatis, Ureaplasma urealyticum, Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Vibrio cholerae, Campylobacter fetus, Brucella species, Bartonella bacilliformis, Klebsiella granulomatis, Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species, Haemophilus influenzae, and Kelbsiella species.

Associated Conditions
Bartonellosis, Brucellosis, Campylobacter fetus, Chancroid, Cholera (Disorder), Conjunctivitis, Inclusion, Granuloma Inguinale, Lymphogranuloma Venereum, Nongonococcal urethritis, Periodontitis, Plague, Psittacosis, Q Fever, Relapsing Fever, Respiratory Tract Infections (RTI), Rickettsia Infections, Rickettsialpox, Rocky Mountain Spotted Fever, Trachoma, Tularemia, Typhus infections, Inflammatory lesions
Associated Therapies
-

A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients

Phase 1
Completed
Conditions
Interventions
First Posted Date
2013-03-06
Last Posted Date
2018-04-26
Lead Sponsor
Augusta University
Target Recruit Count
16
Registration Number
NCT01805895
Locations
🇺🇸

Georgia Health Sciences University, Augusta, Georgia, United States

Kidney and Periodontal Disease Study

First Posted Date
2013-03-01
Last Posted Date
2019-04-30
Lead Sponsor
University of California, San Francisco
Target Recruit Count
51
Registration Number
NCT01802216

Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma

First Posted Date
2013-02-15
Last Posted Date
2021-11-24
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
88
Registration Number
NCT01793051
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer

First Posted Date
2012-12-10
Last Posted Date
2018-06-06
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
22
Registration Number
NCT01746043
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD

First Posted Date
2012-09-27
Last Posted Date
2019-11-13
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
31
Registration Number
NCT01695291
Locations
🇺🇸

Weill Cornell Medical Center, New York, New York, United States

🇺🇸

New York State Psychiatric Institute, New York, New York, United States

Minocycline Study in Pancreatic Cancer Patients

First Posted Date
2012-09-26
Last Posted Date
2020-03-09
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
80
Registration Number
NCT01693523
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Open Treatment of Minocycline in Geriatric Depression

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2012-08-07
Last Posted Date
2017-05-12
Lead Sponsor
Weill Medical College of Cornell University
Target Recruit Count
16
Registration Number
NCT01659320
Locations
🇺🇸

Institute of Geriatric Psychiatry, White Plains, New York, United States

Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy

First Posted Date
2012-07-10
Last Posted Date
2020-07-17
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
51
Registration Number
NCT01636934
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma

First Posted Date
2012-04-19
Last Posted Date
2019-08-16
Lead Sponsor
University of Utah
Target Recruit Count
22
Registration Number
NCT01580969
Locations
🇺🇸

Huntsman Cancer Institute, Salt Lake City, Utah, United States

Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression

Phase 1
Conditions
Interventions
First Posted Date
2012-04-10
Last Posted Date
2012-07-04
Lead Sponsor
Shalvata Mental Health Center
Target Recruit Count
30
Registration Number
NCT01574742
Locations
🇮🇱

Shalvata Medical Health Center, Hod-HaSharon, Israel

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