Overview
Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
Background
Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
Indication
Lumefantrine and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
Associated Conditions
- Uncomplicated Malaria caused by Plasmodium falciparum
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2012/06/08 | Phase 2 | Completed | |||
2010/06/29 | Phase 3 | Completed | University of Lagos, Nigeria | ||
2010/02/25 | Phase 4 | UNKNOWN | |||
2008/11/14 | Phase 4 | Completed | |||
2008/06/18 | Phase 4 | Completed | |||
2008/02/21 | Phase 4 | Completed | |||
2007/10/10 | Phase 3 | Completed | Medicines for Malaria Venture | ||
2007/10/08 | Phase 4 | Completed | |||
2007/08/08 | Not Applicable | Completed | |||
2007/06/11 | Phase 3 | Completed | Dafra Pharma |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
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| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||