比哌立登

概览

Biperiden is a muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.

作用机制

Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.

适应症

用于治疗震颤麻痹及药物引起的锥体外系症状。

• Extrapyramidal Symptoms
• Extrapyramidal disorder caused by neuroleptic drugs without Tardive dyskinesia
• Parkinson's Disease (PD)
• Poisoning caused by Nicotine
• Poisoning caused by organophosphorus pesticides