Overview
A macrocyclic peptide (BMS-986189) with activity in binding and functional assays comparable to a PD-L1 antibody.
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Research Report
Medication Report: anti-OX40 antibody BMS 986178
Name: anti-OX40 antibody BMS 986178 Name (English): anti-OX40 antibody BMS 986178 DrugBank ID: DB15773 Type: Biotech
Description: BMS-986178 is a fully human IgG1 agonistic monoclonal antibody that binds with high affinity to the OX40 receptor (CD134; TNFRSF4). OX40 is a co-stimulatory receptor expressed on T-lymphocytes that, upon activation, promotes the proliferation and survival of activated T-cells. BMS-986178 mimics the action of the endogenous OX40 ligand (OX40L), leading to the activation of the OX40 receptor. This activation can induce the proliferation of memory and effector T-lymphocytes and, in the presence of tumor-associated antigens (TAAs), may enhance an immune response against TAA-expressing tumor cells.
Mechanism of Action: As an agonist monoclonal antibody, BMS-986178 selectively binds to and activates the OX40 receptor on T-cells. This activation provides a co-stimulatory signal, promoting T-cell proliferation, differentiation into effector cells, and survival. In the context of cancer, this enhanced T-cell activity can potentially lead to an improved anti-tumor immune response.
Clinical Trials: BMS-986178 has been evaluated in clinical trials, both as a monotherapy and in combination with other immunotherapeutic agents such as nivolumab (anti-PD-1 antibody) and ipilimumab (anti-CTLA-4 antibody), in patients with advanced solid tumors and low-grade B-cell non-Hodgkin lymphomas. These trials have assessed the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and anti-tumor activity of the drug.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2018/01/25 | Phase 1 | Completed |
FDA Drug Approvals
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| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
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| No Health Canada approvals found for this drug. | |||||
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
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| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
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| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
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| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
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| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
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| No UK EMC drug information found for this drug. | |||||
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