Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Phase 2

Completed

Conditions: Leukemia

First Posted Date: 2008-02-20

Last Posted Date: 2013-03-26

Lead Sponsor: Asan Medical Center

Target Recruit Count: 50

Registration Number: NCT00618501

Locations: 🇰🇷
Asan Medical Center - University of Ulsan College of Medicine, Seoul, Korea, Republic of

Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease

Phase 4

Conditions: Crohn Disease

Interventions: Dietary Supplement: Alicalm (polymeric liquid formula)
Drug: prednisolone

First Posted Date: 2008-02-07

Last Posted Date: 2008-12-30

Lead Sponsor: University Hospital Birmingham

Target Recruit Count: 80

Registration Number: NCT00609752

Locations: 🇬🇧
Sheffield Children's Hospital, Sheffield, South Yorkshire, United Kingdom
🇬🇧
Oxford Children's Hospital, Oxford, Oxfordshire, United Kingdom
🇬🇧
Royal Liverpool Children's Hospital, Liverpool, Merseyside, United Kingdom

and more 3 locations

Multicentre Study to Determine the Cardiotoxicity of R-CHOP Compared to R-COMP in Patients With Diffuse Large B-Cell Lymphoma

Phase 2

Completed

Conditions: Diffuse Large B-Cell Lymphoma

Interventions: Drug: Rituximab
Drug: Cyclophosphamide
Drug: liposomal Doxorubicin
Drug: Doxorubicin
Drug: Vincristin
Drug: Prednisolone

First Posted Date: 2007-12-18

Last Posted Date: 2013-08-30

Lead Sponsor: Arbeitsgemeinschaft medikamentoese Tumortherapie

Target Recruit Count: 94

Registration Number: NCT00575406

Locations: 🇦🇹
Universitaetsklinik Innsbruck/ Klinik für Innere Medizin, Innsbruck, Austria
🇦🇹
A.ö. Landeskrankenhaus Leoben, Leoben, Austria
🇦🇹
Krankenhaus d. Barmherzigen Schwestern Linz, Linz, Austria

and more 7 locations

Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Peripheral T-Cell Lymphoma

Phase 1

Conditions: Lymphoma
Small Intestine Cancer

First Posted Date: 2007-11-21

Last Posted Date: 2013-08-26

Lead Sponsor: Cancer Research UK

Target Recruit Count: 30

Registration Number: NCT00562068

Locations: 🇬🇧
Leeds General Infirmary, Leeds, England, United Kingdom
🇬🇧
Royal Marsden - London, London, England, United Kingdom
🇬🇧
Christie Hospital, Manchester, England, United Kingdom

and more 2 locations

Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease

Not Applicable

Active, not recruiting

Conditions: Asthma
COPD

Interventions: Drug: prednisolone

First Posted Date: 2007-11-08

Last Posted Date: 2021-03-03

Lead Sponsor: Karolinska Institutet

Target Recruit Count: 233

Registration Number: NCT00555607

Locations: 🇸🇪
Karolinska Institutet, Stockholm, Sweden

Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy

Phase 2

Completed

Conditions: Prostate Cancer
Metastatic Cancer

First Posted Date: 2007-11-07

Last Posted Date: 2013-08-07

Lead Sponsor: University Hospital Birmingham

Target Recruit Count: 300

Registration Number: NCT00554918

Locations: 🇬🇧
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust, Birmingham, England, United Kingdom
🇬🇧
Gloucestershire Oncology Centre at Cheltenham General Hospital, Cheltenham, England, United Kingdom
🇬🇧
Christie Hospital, Manchester, England, United Kingdom

and more 13 locations

Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid Arthritis

Phase 2

Completed

Conditions: Rheumatoid Arthritis

Interventions: Drug: CRx-102 (2.7/180)
Drug: placebo
Drug: prednisolone
Drug: dipyridamole
Drug: CRx-102 (2.7/360)

First Posted Date: 2007-10-31

Last Posted Date: 2014-04-29

Lead Sponsor: Zalicus

Target Recruit Count: 51

Registration Number: NCT00551707

Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

Not Applicable

Conditions: Leukemia

First Posted Date: 2007-10-30

Last Posted Date: 2019-07-30

Lead Sponsor: Dutch Childhood Oncology Group

Target Recruit Count: 445

Registration Number: NCT00550992

Locations: 🇨🇿
University Hospital Motol, Prague, Czechia
🇫🇷
CHR Hotel Dieu, Nantes, France
🇺🇸
Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington, United States

and more 10 locations