Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Rituximab Plus Combination Chemotherapy in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma

Phase 1

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-20

Lead Sponsor: Lymphoma Trials Office

Registration Number: NCT00031902

Locations: 🇬🇧
Chelsea Westminster Hospital, London, United Kingdom
🇬🇧
St. George's Hospital, London, England, United Kingdom

Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia

Phase 3

Completed

Conditions: Leukemia

First Posted Date: 2003-01-27

Last Posted Date: 2013-12-18

Lead Sponsor: Leukemia Research Fund

Registration Number: NCT00004218

Locations: 🇮🇹
Ospedali Riuniti di Bergamo, Bergamo, Italy
🇮🇪
St. James' Hospital, Dublin, Ireland
🇬🇧
North Hampshire Hospital, Basingstoke, England, United Kingdom

and more 82 locations

Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Phase 3

Conditions: Leukemia

First Posted Date: 2003-01-27

Last Posted Date: 2013-12-04

Lead Sponsor: Medical Research Council

Target Recruit Count: 1800

Registration Number: NCT00003437

Locations: 🇬🇧
Oxford Radcliffe Hospital, Oxford, England, United Kingdom

Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma

Phase 3

Completed

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-06-26

Lead Sponsor: Lymphoma Trials Office

Target Recruit Count: 310

Registration Number: NCT00005867

Locations: 🇬🇧
Horton Hospital, Banbury, England, United Kingdom
🇬🇧
Hinchingbrooke Hospital, Huntingdon, England, United Kingdom
🇬🇧
Hull Royal Infirmary, Hull, England, United Kingdom

and more 43 locations

Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia

Phase 3

Completed

Conditions: Leukemia
Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-06-12

Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Target Recruit Count: 392

Registration Number: NCT00002700

Locations: 🇸🇰
Institute of Hematology & Transfusiology, University Hospital, Bratislava, Slovakia
🇧🇪
Hopital Universitaire Erasme, Brussels, Belgium
🇧🇪
Universitair Ziekenhuis Antwerpen, Edegem, Belgium

and more 41 locations

Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia

Phase 3

Completed

Conditions: Leukemia

Interventions: Drug: asparaginase
Drug: cytarabine
Drug: mercaptopurine
Drug: methotrexate
Drug: prednisolone
Drug: vincristine sulfate

First Posted Date: 2003-01-27

Last Posted Date: 2014-02-17

Lead Sponsor: Dutch Childhood Oncology Group

Target Recruit Count: 350

Registration Number: NCT00015873

Locations: 🇮🇹
Ospedale San Gerardo, Monza, Italy
🇳🇱
Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
🇬🇧
Royal Liverpool Children's Hospital, Alder Hey, Liverpool, England, United Kingdom

and more 29 locations

Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma

Phase 2

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-07

Lead Sponsor: Children's Cancer and Leukaemia Group

Target Recruit Count: 260

Registration Number: NCT00025064

Locations: 🇬🇧
Birmingham Children's Hospital, Birmingham, England, United Kingdom
🇬🇧
Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, United Kingdom
🇬🇧
Leeds Cancer Centre at St. James's University Hospital, Leeds, England, United Kingdom

and more 17 locations

TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma

Phase 3

Completed

Conditions: Leukemia
Lymphoma

Interventions: Biological: filgrastim
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: cytarabine
Drug: prednisone
Drug: methotrexate
Drug: prednisolone
Drug: etoposide
Drug: therapeutic hydrocortisone
Drug: vincristine sulfate

First Posted Date: 2003-01-27

Last Posted Date: 2014-07-24

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 1148

Registration Number: NCT00002757

Locations: 🇫🇷
Institut Gustave Roussy, Villejuif, France
🇬🇧
Children's Hospital - Sheffield, Sheffield, England, United Kingdom

Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma

Phase 3

Conditions: Leukemia
Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2011-01-21

Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Target Recruit Count: 1500

Registration Number: NCT00003728

Locations: 🇵🇹
Hospital Escolar San Joao, Porto, Portugal
🇵🇹
Instituto Portugues de Oncologia Centro do Porto, SA, Porto, Portugal
🇫🇷
CHR de Besancon - Hopital Saint-Jacques, Besancon, France

and more 20 locations

Combination Chemotherapy Plus Filgrastim in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma

Phase 1

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-20

Lead Sponsor: Lymphoma Trials Office

Target Recruit Count: 30

Registration Number: NCT00032149

Locations: 🇬🇧
King's College Hospital, London, England, United Kingdom
🇬🇧
St. Georges, University of London, London, England, United Kingdom
🇬🇧
Cheltenham General Hospital, Cheltenham, England, United Kingdom

and more 1 locations

Drug Development Updates

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