Prednisolone

Generic Name: Prednisolone

Brand Names: Millipred Dp 6 Day

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₈O_₅

CAS Number: 50-24-8

Unique Ingredient Identifier: 9PHQ9Y1OLM

Background: Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.

Prednisolone was granted FDA approval on 21 June 1955.

Indication: Prednisolone is indicated to treat endocrine, rheumatic, and hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, and gastrointestinal diseases; allergic and edematous states; and other conditions like tuberculous meningitis.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Contact Dermatitis, Allergic Skin Reaction, Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonia, Aspiration Pneumonitis, Atopic Dermatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Burns, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Corneal injuries, Corneal ulceration, Crohn's Disease (CD), Cyclitis, Dermatomyositis (DM), Dermatosis of the Ear Canal, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Exacerbation of COPD, Exacerbation of asthma, Eye inflammation caused by Cataract Surgery, Eye inflammation caused by Infection, Fissure;Anal, Herpes Zoster Keratitis, Hot Water Burns (Scalds), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Inflamed External Hemorrhoid, Inflamed Hemorrhoids, Internal, Inflammatory Reaction caused by susceptible Bacterial Infections, Iridocyclitis, Iritis, Itching caused by susceptible Bacterial Infections, Keratitis, Loeffler's syndrome, Lymphoma, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Otic Eczema, Pemphigus, Perennial Allergic Rhinitis (PAR), Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Posterior Uveitis, Posttraumatic Osteoarthritis, Proctitis, Proteinuria, Pruritus, Pruritus Ani, Psoriatic Arthritis, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Rash, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Seasonal Allergic Rhinitis, Secondary Adrenal Insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Asthma, Sjogren's Syndrome (SS), Stevens-Johnson Syndrome, Superficial punctate keratitis, Synovitis, Systemic Lupus Erythematosus, Transplanted Organ Rejection, Trichinosis, Tuberculosis (TB), Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Rheumatic heart disease, unspecified, Acute Tenosynovitis, Anal eczema, Bacterial skin infections, Exfoliative erythroderma, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Primary adrenocoritical insufficiency, Severe Psoriasis, Severe Seborrhoeic dermatitis, Severe alcoholic liver disease, Steroid-responsive inflammation of the eye, Subacute Bursitis, Susceptible Bacterial Infections, Symptomatic Sarcoidosis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: -

Clinical Trials

Comparison of Relapse Rate After 12 Weeks Verses 20 Weeks Steroid Therapy for the Management of First Episode of Steroid Sensitive Nephrotic Syndrome

Not Applicable

Conditions: Steroid-Sensitive Nephrotic Syndrome

Interventions: Drug: Prednisolone

First Posted Date: 2021-01-19

Last Posted Date: 2021-05-11

Lead Sponsor: Shaheed Zulfiqar Ali Bhutto Medical University

Target Recruit Count: 68

Registration Number: NCT04713410

Locations: 🇵🇰
Pakistan Institute of Medical Sciences, Islamabad, Capital, Pakistan

Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus

Phase 2

Completed

Conditions: Erosive Lichen Planus

Interventions: Drug: Lycopene Softgel, 10 Mg
Drug: Prednisolone

First Posted Date: 2020-12-03

Last Posted Date: 2020-12-03

Lead Sponsor: Nourhan M.Aly

Target Recruit Count: 20

Registration Number: NCT04652739

Locations: 🇪🇬
Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis

Phase 3

Recruiting

Conditions: Reduction
Psoriatic Arthritis
Withdrawal

Interventions: Drug: Prednisolone
Drug: Sulfasalazine
Drug: Leflunomide
Drug: Methotrexate
Drug: Tofacitinib
Drug: Apremilast
Drug: Etanercept
Drug: Adalimumab
Drug: Infliximab
Drug: Certolizumab pegol
Drug: Golimumab
Drug: Abatacept
Drug: Secukinumab
Drug: Ixekizumab
Drug: Ustekinumab

First Posted Date: 2020-10-30

Last Posted Date: 2022-11-14

Lead Sponsor: University of Erlangen-Nürnberg Medical School

Target Recruit Count: 270

Registration Number: NCT04610476

Locations: 🇩🇪
Universitätsklinikum Erlangen, Erlangen, Bavaria, Germany

Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults With Type 2 Diabetes

Phase 2

Completed

Conditions: Diabetes Mellitus, Type 2

Interventions: Drug: AZD9567
Drug: Prednisolone
Other: Placebo

First Posted Date: 2020-09-21

Last Posted Date: 2024-07-18

Lead Sponsor: AstraZeneca

Target Recruit Count: 46

Registration Number: NCT04556760

Locations: 🇩🇪
Research Site, Neuss, Germany

Study of Initial Steroid Treatment in Young Children With Nephrotic Syndrome

Phase 3

Withdrawn

Conditions: Steroid-Sensitive Nephrotic Syndrome

Interventions: Drug: Placebo
Drug: Prednisolone

First Posted Date: 2020-09-02

Last Posted Date: 2020-12-17

Lead Sponsor: Children's Hospital of Fudan University

Registration Number: NCT04536181

Locations: 🇨🇳
Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
🇨🇳
Children's hospital of Fudan university, Shanghai, Shanghai, China
🇨🇳
Shanghai Children's Hospital, Shanghai, China

and more 1 locations