Osenvelt is a medicine used to prevent bone complications in adults with advanced cancer that has spread to the bone. These complications include fractures (breaks in the bone), spinal compression (pressure on the spinal cord caused by damage to the surrounding bone), or bone problems requiring radiotherapy (treatment with radiation) or surgery. Osenvelt is also used to treat a type of bone cancer called giant cell tumour of bone in adults and in adolescents whose bones have fully developed. It is used in patients who cannot be treated by surgery or in whom surgery is likely to cause serious complications. Osenvelt is a biological medicine and contains the active substance denosumab. It is a ‘biosimilar medicine’; this means that Osenvelt is highly similar to another biological medicine (the ‘reference medicine’) that is already authorised in the EU. The reference medicine for Osenvelt is Xgeva. For more information on biosimilar medicines, see [here](https://www.ema.europa.eu/en/human-regulatory/overview/biosimilar-medicines).
Therapeutic Indication
### Therapeutic indication Prevention of skeletal related events (pathological fracture, radiation to bone, spinal cord compression or surgery to bone) in adults with advanced malignancies involving bone (see section 5.1). Treatment of adults and skeletally mature adolescents with giant cell tumour of bone that is unresectable or where surgical resection is likely to result in severe morbidity.
Therapeutic Area (MeSH)
ATC Code
M05BX04
ATC Item
denosumab
Pharmacotherapeutic Group
Drugs for treatment of bone diseases
Active Substance (Summary)
INN / Common Names
| Substance | CAS | Monograph |
|---|---|---|
| denosumab | N/A | 地舒单抗 |
EMA Name
Osenvelt
Medicine Name
Osenvelt
Aliases
N/ANo risk management plan link.