<p>Columvi is a cancer medicine used to treat adults with diffuse large B-cell lymphoma (DLBCL), a cancer affecting B cells (a type of white blood cell). Columvi is used in patients whose cancer has returned (relapsed) or stopped responding (refractory) after at least two previous treatments.</p><p>In adults with a type of DLBCL called DLBCL NOS (not otherwise specified), it can be used in combination with two other cancer medicines, gemcitabine and oxaliplatin, when the disease is relapsed or refractory and patients cannot have an autologous stem cell transplant (a transplant of the patient’s own blood-producing cells).</p><p>DLBCL is rare, and Columvi was designated an ‘orphan medicine’ (a medicine used in rare diseases) on 15 October 2021. Further information on the orphan designation can be found on the EMA <a href="https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-21-2497">website</a>.</p><p>Columvi contains the active substance glofitamab.</p>
Therapeutic Indication
<div class="subsection mt-3-5"> <h3>Therapeutic indication</h3><p>Columvi in combination with gemcitabine and oxaliplatin is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) who are ineligible for autologous stem cell transplant (ASCT).<br><br>Columvi as monotherapy is indicated for the treatment of adult patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), after two or more lines of systemic therapy.</p></div>
Therapeutic Area (MeSH)
ATC Code
L01FX28
ATC Item
N/A
Pharmacotherapeutic Group
Antineoplastic agents
Active Substance (Summary)
INN / Common Names
| Substance | CAS | Monograph |
|---|---|---|
| Glofitamab | N/A | Glofitamab |
EMA Name
Columvi
Medicine Name
Columvi
Aliases
N/ANo risk management plan link.