<p>Deqsiga is a medicine used to treat people who:</p><ul><li>are at risk of infection because they lack a type of antibody called immunoglobulin G (IgG), which is a protein in the blood that helps the body fight infections. Deqsiga is used in people who are born with a lack of IgG (primary immunodeficiency syndrome, PID) and those who developed a lack of IgG after birth (secondary immunodeficiency syndrome, SID) and have infections that are severe or keep coming back, and for which medicines used to treat infections do not work;</li><li>have certain immune diseases (caused by the body’s own defence system attacking normal tissues), to help the activity of the immune system (immunomodulation). Deqsiga is used in patients with:<ul><li>primary immune thrombocytopenia (ITP), a disease associated with a lack of platelets (components in the blood that help it to clot) which puts patients at risk of bleeding;</li><li>Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy, inflammatory disorders of the nerves that result in muscle weakness and numbness;</li><li>Kawasaki disease, a disease mainly seen in children which causes inflammation of blood vessels;</li><li>multifocal motor neuropathy, nerve damage which causes weakness of the arms and legs.</li></ul></li></ul><p>Deqsiga contains the active substance human normal immunoglobulin.</p>
Therapeutic Indication
<div class="subsection mt-3-5"> <h3>Therapeutic indication</h3><p>Replacement therapy in adults, children and adolescents (0 to 18 years) in:<br> - Primary immunodeficiency syndromes (PID) with impaired antibody production. <br> - Secondary immunodeficiencies (SID) in patients who suffer from severe or recurrent infections, ineffective antimicrobial treatment and either <strong>proven specific antibody failure (PSAF)*</strong> or serum IgG level of < 4 g/L.<br><br>*PSAF = failure to mount at least a 2-fold rise in IgG antibody titre to pneumococcal polysaccharide and polypeptide antigen vaccines<br><br>Immunomodulation in adults, children and adolescents (0 to 18 years) in:<br> - Primary immune thrombocytopenia (ITP), in patients at high risk of bleeding or prior to surgery to correct the platelet count.<br> - Guillain Barré syndrome.<br> - Kawasaki disease (in conjunction with acetylsalicylic acid; see section 4.2).<br> - Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).<br> - Multifocal Motor Neuropathy (MMN).</p></div>
Therapeutic Area (MeSH)
ATC Code
J06BA02
ATC Item
N/A
Pharmacotherapeutic Group
Immune sera and immunoglobulins
Active Substance (Summary)
INN / Common Names
| Substance | CAS | Monograph |
|---|---|---|
| human normal immunoglobulin | N/A | human normal immunoglobulin |
EMA Name
Deqsiga
Medicine Name
Deqsiga
Aliases
N/ANo risk management plan link.