Lyvdelzi (previously Seladelpar Gilead)

Seladelpar Gilead is a medicine used to treat adults with a liver disease known as primary biliary cholangitis. Primary biliary cholangitis is an autoimmune condition in which there is gradual destruction of the bile ducts in the liver. These ducts transport a fluid called bile from the liver to the intestines, where it is used to help digest fats. As a result of the damage to the ducts, bile builds up in the liver, causing damage to liver tissue. This may lead to scarring and liver failure and may increase the risk of liver cancer. Seladelpar Gilead is used together with another medicine, ursodeoxycholic acid (UDCA), in patients for whom UDCA alone does not work well enough, and on its own in patients who cannot take UDCA. Primary biliary cholangitis is rare, and Seladelpar Gilead was designated an ‘orphan medicine’ (a medicine used in rare diseases) on 16 October 2017. Seladelpar Gilead contains the active substance seladelpar.