Clopidogrel Zentiva is a medicine used to prevent problems caused by blood clots in adults who have: - recently had a myocardial infarction (heart attack). Clopidogrel Zentiva can be started between a few days and 35 days after the attack; - recently had an ischaemic stroke (stroke caused by failure of the blood supply to part of the brain). Clopidogrel Zentiva can be started between seven days and six months after the stroke; - peripheral arterial disease (problems with blood flow in the arteries); - a condition known as ‘acute coronary syndrome’, when it should be given with acetylsalicylic acid (another medicine that prevents blood clots). Acute coronary syndrome is a group of heart problems that include severe heart attacks (known as ST-elevation myocardial infarction) and unstable angina (a severe type of chest pain). Some of these patients may be undergoing percutaneous coronary intervention (a procedure that unblocks blood vessels of the heart to restore its blood supply) and may have had a stent inserted (a short tube placed in an artery to prevent it closing up). Others may benefit from thrombolytic or fibrinolytic treatment (treatments to dissolve blood clots). - atrial fibrillation (irregular rapid contractions of the upper chambers of the heart), when it should be given with acetylsalicylic acid. It is used in those patients who have at least one risk factor for vascular events such as a heart attack or stroke, cannot take vitamin K antagonists (other medicines that prevent blood clots) and are at low risk of bleeding. Clopidogrel Zentiva contains the active substance clopidogrel.
Therapeutic Indication
### Therapeutic indication Secondary prevention of atherothrombotic events Clopidogrel is indicated in: - adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from seven days until less than six months) or established peripheral arterial disease; - adult patients suffering from acute coronary syndrome: - non-ST-segment-elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), including patients undergoing a stent placement following percutaneous coronary intervention, in combination with acetylsalicylic acid (ASA); - ST-segment-elevation acute myocardial infarction, in combination with ASA in medically treated patients eligible for thrombolytic therapy. Prevention of atherothrombotic and thromboembolic events in atrial fibrillation In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with vitamin-K antagonists and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke. For further information please refer to section 5.1.
Therapeutic Area (MeSH)
ATC Code
B01AC04
ATC Item
clopidogrel
Pharmacotherapeutic Group
Antithrombotic agents
Active Substance (Summary)
INN / Common Names
| Substance | CAS | Monograph |
|---|---|---|
| clopidogrel | N/A | 氯吡格雷 |
EMA Name
Clopidogrel Zentiva (previously Clopidogrel Winthrop)
Medicine Name
Clopidogrel Zentiva (previously Clopidogrel Winthrop)
Aliases
N/ANo risk management plan link.