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FDA Approval

Nighttime Sleep-Aid

FDA-approved pharmaceutical product with comprehensive regulatory information, manufacturing details, and complete labeling documentation.

FDA Approval Summary

Company
Effective Date
May 21, 2025
Labeling Type
HUMAN OTC DRUG LABEL
Diphenhydramine(50 mg in 1 1)

Registrants1

Companies and organizations registered with the FDA for this drug approval, including their contact information and regulatory details.

Bionpharma Inc.

079637826

Manufacturing Establishments1

FDA-registered manufacturing facilities and establishments involved in the production, packaging, or distribution of this drug product.

SOFTGEL HEALTHCARE PRIVATE LIMITED

Whole Foods Market, INC.

Bionpharma Inc.

675584180

Products1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Nighttime Sleep-Aid

Product Details

NDC Product Code
42681-0051
Application Number
M010
Marketing Category
OTC Monograph Drug (C200263)
Route of Administration
ORAL
Effective Date
May 21, 2025
POLYETHYLENE GLYCOL 600Inactive
Code: NL4J9F21N9Class: IACT
SORBITANInactive
Code: 6O92ICV9RUClass: IACT
GELATINInactive
Code: 2G86QN327LClass: IACT
POLYETHYLENE GLYCOL 400Inactive
Code: B697894SGQClass: IACT
WATERInactive
Code: 059QF0KO0RClass: IACT
GLYCERINInactive
Code: PDC6A3C0OXClass: IACT
PROPYLENE GLYCOLInactive
Code: 6DC9Q167V3Class: IACT
SORBITOLInactive
Code: 506T60A25RClass: IACT
Code: TC2D6JAD40Class: ACTIBQuantity: 50 mg in 1 1

Drug Labeling Information

Complete FDA-approved labeling information including indications, dosage, warnings, contraindications, and other essential prescribing details.

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

32s count

NDC 42681-0051-1

365

WHOLE FOODS

MARKET

Nighttime

Sleep-Aid

Diphenhydramine HCl

Capsules USP, 50 mg

Maximum Strength

Fall asleep fast & Sleep Soundly

safe, non habit-forming

Compare to the Active Ingredient in****Unisom®**SleepGels®

One softgel per dose

32

SOFTGELS*

*Liquid-filled capsules

carton


INDICATIONS & USAGE SECTION

Uses

■ for relief of occasional sleeplessness ■ reduces time to fall asleep if you have difficulty falling asleep

DOSAGE & ADMINISTRATION SECTION

Directions

■**Adults and children 12 years of age and over:**One softgel (50 mg) at bedtime if needed, or as directed by a doctor.
■ swallow whole; do not crush, chew, or dissolve


WARNINGS SECTION

Warnings

Do not use

■ for children under 12 years of age

■ with any other product containing diphenhydramine, even one used on skin.


STORAGE AND HANDLING SECTION

Other information

■ store at 20°C to 25°C (68°F to 77°F) ■ avoid high humidity and excessive heat above 40°C (104°F).
■ protect from light


OTC - ACTIVE INGREDIENT SECTION

Active ingredient (in each capsule)

Diphenhydramine HCl 50 mg

OTC - PURPOSE SECTION

Purpose

Nighttime sleep-aid

OTC - ASK DOCTOR SECTION

Ask a doctor before use if you have

■ glaucoma ■ a breathing problem such as emphysema or chronic bronchitis

■ difficulty in urination due to enlargement of the prostate gland

OTC - ASK DOCTOR/PHARMACIST SECTION

Ask a doctor or pharmacist before use

if you are taking sedatives or tranquilizers.

OTC - KEEP OUT OF REACH OF CHILDREN SECTION

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

OTC - STOP USE SECTION

Stop use and ask a doctor if

sleeplessness persists continuosly for more than 2 weeks, consult your doctor. Insomnia may be a symptom of serious underlying medical illness.

OTC - WHEN USING SECTION

When using this product

■ avoid alcoholic beverages ■ be careful when driving a motor vehicle or operating machinery

OTC - QUESTIONS SECTION

Questions or comments?

call toll-free1-888-235-2466 (Mon - Fri 9AM - 5PM EST)

OTC - PREGNANCY OR BREAST FEEDING SECTION

If pregnant or breast- feeding,

ask a health professional before use.


SPL UNCLASSIFIED SECTION

DO NOT USE IF TAMPER-EVIDENT SEAL UNDER BOTTLE CAP IS BROKEN OR MISSING.

READ AND KEEP CARTON FOR COMPLETE WARNINGS AND INFORMATION

DISTRIBUTED BY: WHOLE FOODS MARKET I 550 BOWIE STREET, AUSTIN, TX 78703
©2020 WHOLE FOODS MARKET IP, INC. I www.wholefoodsmarket.com
PRODUCT OF INDIA I**THIS PRODUCT IS NOT MANUFACTURED OR DISIRIBUTED BY THE OWNERS OF UNISOM® SLEEPGELS®

L0000950 R0125

Mfg. Lic. No.: TN00002123

Lot No.:

Exp. Date:

INACTIVE INGREDIENT SECTION

Inactive ingredients

gelatin, glycerin, polyethylene glycol 400, polyethylene glycol 600, propylene glycol, purified water, sorbitol sorbitan solution


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