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FDA Approval

Dihydroergotamine Mesylate

FDA-approved pharmaceutical product with comprehensive regulatory information, manufacturing details, and complete labeling documentation.

FDA Approval Summary

Company
Gland Pharma Limited
DUNS: 918601238
Effective Date
August 22, 2023
Labeling Type
Human Prescription Drug Label
Dihydroergotamine(1 mg in 1 mL)

Manufacturing Establishments1

FDA-registered manufacturing facilities and establishments involved in the production, packaging, or distribution of this drug product.

Gland Pharma Limited

Gland Pharma Limited

858971074

Products1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Dihydroergotamine Mesylate

Product Details

NDC Product Code
68083-466
Application Number
ANDA215623
Marketing Category
ANDA (C73584)
Route of Administration
INTRAVENOUS, INTRAMUSCULAR, SUBCUTANEOUS
Effective Date
August 22, 2023
Code: 81AXN7R2QTClass: ACTIBQuantity: 1 mg in 1 mL
METHANESULFONIC ACIDInactive
Code: 12EH9M7279Class: IACT
WATERInactive
Code: 059QF0KO0RClass: IACT
GLYCERINInactive
Code: PDC6A3C0OXClass: IACT
SODIUM HYDROXIDEInactive
Code: 55X04QC32IClass: IACT
ALCOHOLInactive
Code: 3K9958V90MClass: IACT

Drug Labeling Information

Complete FDA-approved labeling information including indications, dosage, warnings, contraindications, and other essential prescribing details.

DESCRIPTION SECTION

DESCRIPTION

Dihydroergotamine mesylate is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. Dihydroergotamine mesylate is known chemically as ergotaman-3´,6´,18-trione,9,10-dihydro-12´-hydroxy-2´-methyl-5´-(phenylmethyl)-,(5´α)-, monomethanesulfonate. Its molecular weight is 679.78 and its empirical formula C34H41N5O8S.

The chemical structure is

dhe-structure

Dihydroergotamine mesylate
C34H41N5O8S. Mol. Wt. 679.78

Dihydroergotamine Mesylate Injection, USP is a clear, colorless solution supplied in sterile ampules for intravenous, intramuscular, or subcutaneous administration. Each mL contains 1 mg Dihydroergotamine Mesylate, USP; Alcohol, USP 6.1% by volume; Glycerin, USP 15% by weight; Water for Injection, USP; Methanesulfonic Acid and/or Sodium Hydroxide for pH adjustment (pH range is 3.4 to 4.9).


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