MedPath

CloSYS

CloSYS SILVER Gentle Fluoride TOOTHPASTE

Approved
Approval ID

ed617c7a-805c-4788-9bce-9b7fead4312d

Product Type

HUMAN OTC DRUG LABEL

Effective Date

May 16, 2025

Manufacturers
FDA

Rowpar Pharmaceuticals, Inc.

DUNS: 783704661

Products 1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Sodium fluoride

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code58578-0759
Application NumberM021
Product Classification
M
Marketing Category
C200263
G
Generic Name
Sodium fluoride
Product Specifications
Route of AdministrationORAL
Effective DateMay 16, 2025
FDA Product Classification

INGREDIENTS (12)

SODIUM FLUORIDEActive
Quantity: 0.916 mg in 1 g
Code: 8ZYQ1474W7
Classification: ACTIM
WATERInactive
Code: 059QF0KO0R
Classification: IACT
HYDRATED SILICAInactive
Code: Y6O7T4G8P9
Classification: IACT
CHLORINE DIOXIDEInactive
Code: 8061YMS4RM
Classification: IACT
CARBOXYMETHYLCELLULOSEInactive
Code: 05JZI7B19X
Classification: IACT
SODIUM PHOSPHATE, DIBASIC, ANHYDROUSInactive
Code: 22ADO53M6F
Classification: IACT
TITANIUM DIOXIDEInactive
Code: 15FIX9V2JP
Classification: IACT
PEPPERMINT OILInactive
Code: AV092KU4JH
Classification: IACT
SODIUM PHOSPHATE, MONOBASIC, ANHYDROUSInactive
Code: KH7I04HPUU
Classification: IACT
SODIUM MYRISTOYL SARCOSINATEInactive
Code: J07237209D
Classification: IACT
SUCRALOSEInactive
Code: 96K6UQ3ZD4
Classification: IACT
MENTHOL, UNSPECIFIED FORMInactive
Code: L7T10EIP3A
Classification: IACT

Drug Labeling Information

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

LOINC: 51945-4Updated: 12/20/2022

Packaging

GENTLE MINT

A CLEANER MOUTH
A HEALTHIER YOU®

CLōSYS**®******
SILVER**®**
Gentlest. Oral Care. Ever®

for ADULTS 55+
MULTI-BENEFIT TOOTHPASTE

Anticavity Protection
Remineralizes Enamel
Freshens Breath
Gentle / Non-irritating

ADA Accepted
American Dental Association

3.4 oz
(96g)

ADA Accepted
American Dental Association
Helps prevent cavities

pH balanced

Naturally activated for faster results

Strengthens Enamel

SULFATE-FREE

Dist by:
Rowpar Pharmaceutical, Inc.
Scottsdale, AZ 85260
CloSYS.com

55034-37

MADE IN THE
USA

Carton Label

GENTLE MINT

A CLEANER MOUT
A HEALTHIER YOU**®**

CLōSYS®** SILVER**®
Gentlest. Oral Care. Ever®

for ADULTS 55+
MULTI-BENEFIT TOOTHPASTE

Anticavity Protection
Remineralizes Enamel
Freshens Breath
Gentle / Non-irritating

3.4 oz
(96g)

Use of standardized chlorine dioxide is protected under U.S. & foreign patents-see CloSYS.com/patents

ADA Accepted
American Dental Association

Helps prevent cavities

Dist by:
Rowpar Pharmaceutical, Inc.
Scottsdale, AZ 85260
CloSYS.com

MADE IN THE
USA


****54534-56

Tube Label

INDICATIONS & USAGE SECTION

LOINC: 34067-9Updated: 12/19/2022

USES:

aids in the prevention of dental decay

SPL UNCLASSIFIED SECTION

LOINC: 42229-5Updated: 12/19/2022

** Drug Facts**

OTC - ACTIVE INGREDIENT SECTION

LOINC: 55106-9Updated: 12/19/2022

ACTIVE INGREDIENT:

Sodium fluoride 0.21% (0.11% w/v fluoride ion)

OTC - PURPOSE SECTION

LOINC: 55105-1Updated: 12/19/2022

PURPOSE:

Anticavity

WARNINGS SECTION

LOINC: 34071-1Updated: 12/19/2022

WARNINGS:

Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.

DOSAGE & ADMINISTRATION SECTION

LOINC: 34068-7Updated: 12/19/2022

DIRECTIONS:

Adults and children 2 years of age and older: brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor.
Children under 6 years of age:
**·**instruct in good brushing and rinsing habits (to minimize swallowing).
**·**supervise children as necessary until capable of using without supervision.
**·**do not swallow
Children under 2 years of age:
****Consult a dentist or doctor

INACTIVE INGREDIENT SECTION

LOINC: 51727-6Updated: 12/20/2022

INACTIVE INGREDIENTS:

water, hydrated silica, stabilized chlorine dioxide, cellulose gum, disodium hydrogen phosphate, titanium dioxide, peppermint oil, sodium dihydrogen phosphate, sodium myristoyl sarcosinate (coconut derived), sucralose, menthol crystals

OTC - QUESTIONS SECTION

LOINC: 53413-1Updated: 12/19/2022

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CloSYS - FDA Drug Approval Details