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Alprazolam

These highlights do not include all the information needed to use ALPRAZOLAM EXTENDED-RELEASE TABLETS safely and effectively. See full prescribing information for ALPRAZOLAM EXTENDED-RELEASE TABLETS. ALPRAZOLAM extended-release tablets, for oral use, CIV Initial U.S. Approval: 1981

Approved
Approval ID

aaab422d-c763-4352-8ffc-5aafdf91e8dd

Product Type

HUMAN PRESCRIPTION DRUG LABEL

Effective Date

Aug 20, 2025

Manufacturers
FDA

Bryant Ranch Prepack

DUNS: 171714327

Products 1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Alprazolam

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code71335-1839
Application NumberANDA090871
Product Classification
M
Marketing Category
C73584
G
Generic Name
Alprazolam
Product Specifications
Route of AdministrationORAL
Effective DateAugust 20, 2025
FDA Product Classification

INGREDIENTS (7)

ALPRAZOLAMActive
Quantity: 1 mg in 1 1
Code: YU55MQ3IZY
Classification: ACTIB
SILICON DIOXIDEInactive
Code: ETJ7Z6XBU4
Classification: IACT
LACTOSE MONOHYDRATEInactive
Code: EWQ57Q8I5X
Classification: IACT
MAGNESIUM STEARATEInactive
Code: 70097M6I30
Classification: IACT
D&C YELLOW NO. 10Inactive
Code: 35SW5USQ3G
Classification: IACT
HYPROMELLOSE 2208 (4000 MPA.S)Inactive
Code: 39J80LT57T
Classification: IACT
HYPROMELLOSE 2208 (100 MPA.S)Inactive
Code: B1QE5P712K
Classification: IACT

Drug Labeling Information

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

LOINC: 51945-4Updated: 8/20/2025

Alprazolam ER 1mg (CIV) Tablet

Label

RECENT MAJOR CHANGES SECTION

LOINC: 43683-2Updated: 8/20/2025

RECENT MAJOR CHANGES

Boxed Warning 2/2021

Dosage and Administration (2.3) 2/2021

Warnings and Precautions (5.2, 5.3) 2/2021

DESCRIPTION SECTION

LOINC: 34089-3Updated: 1/12/2022

11 DESCRIPTION

Alprazolam extended-release tablets USP contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds.

The chemical name of alprazolam is 8-chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-α] [1,4] benzodiazepine. The molecular formula is C17H13ClN4 which corresponds to a molecular weight of 308.76.

The structural formula is represented below:

Chemical Structure

Alprazolam USP is a white to off-white, crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH.

Each alprazolam extended-release tablet USP, for oral administration, contains 0.5 mg, 1 mg, 2 mg, or 3 mg of alprazolam USP. The inactive ingredients are colloidal silicon dioxide, hypromellose, lactose monohydrate, and magnesium stearate. In addition, the 1 mg and 3 mg tablets contain D&C Yellow No. 10 aluminum lake and the 2 mg and 3 mg tablets contain FD&C Blue No. 2 lake.

Meets USP Dissolution Test 4.

HOW SUPPLIED SECTION

LOINC: 34069-5Updated: 8/20/2025

16 HOW SUPPLIED/STORAGE AND HANDLING

Alprazolam Extended-Release Tablets USP, 1 mg are yellow colored, round, biconvex tablets with beveled edge debossed with ‘X’ on one

side and ‘73’ on the other side.

NDC: 71335-1839-1: 30 Tablets in a BOTTLE

NDC: 71335-1839-2: 60 Tablets in a BOTTLE

NDC: 71335-1839-3: 90 Tablets in a BOTTLE

NDC: 71335-1839-4: 28 Tablets in a BOTTLE

NDC: 71335-1839-5: 120 Tablets in a BOTTLE

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].

Repackaged/Relabeled by:

Bryant Ranch Prepack, Inc.

Burbank, CA 91504

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Alprazolam - FDA Drug Approval Details