MedPath

CloSYS

CloSYS Fluoride Toothpaste

Approved
Approval ID

5f87abb7-0e9d-6369-e053-2a91aa0a2411

Product Type

HUMAN OTC DRUG LABEL

Effective Date

May 16, 2025

Manufacturers
FDA

Rowpar Pharmaceuticals, Inc.

DUNS: 783704661

Products 1

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Sodium Fluoride

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code58578-0749
Application NumberM021
Product Classification
M
Marketing Category
C200263
G
Generic Name
Sodium Fluoride
Product Specifications
Route of AdministrationORAL, DENTAL
Effective DateMay 16, 2025
FDA Product Classification

INGREDIENTS (12)

SUCRALOSEInactive
Code: 96K6UQ3ZD4
Classification: IACT
SODIUM PHOSPHATE, MONOBASIC, ANHYDROUSInactive
Code: KH7I04HPUU
Classification: IACT
SODIUM PHOSPHATE, DIBASIC, ANHYDROUSInactive
Code: 22ADO53M6F
Classification: IACT
CARBOXYMETHYLCELLULOSEInactive
Code: 05JZI7B19X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
TITANIUM DIOXIDEInactive
Code: 15FIX9V2JP
Classification: IACT
HYDRATED SILICAInactive
Code: Y6O7T4G8P9
Classification: IACT
CHLORINE DIOXIDEInactive
Code: 8061YMS4RM
Classification: IACT
SODIUM FLUORIDEActive
Quantity: 1.1 mg in 1 g
Code: 8ZYQ1474W7
Classification: ACTIM
PEPPERMINT OILInactive
Code: AV092KU4JH
Classification: IACT
MENTHOLInactive
Code: L7T10EIP3A
Classification: IACT
SODIUM LAUROYL SARCOSINATEInactive
Code: 632GS99618
Classification: IACT

Drug Labeling Information

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

LOINC: 51945-4Updated: 12/18/2023

Principal Display Panel

Closys®
Anticavity Fluoride Toothpaste

SULFATE-FREE

NEW LOOK!

A CLEANER MOUTH
A HEALTHIER YOU®

CLoSYS ®
Anticavity Fluoride Toothpaste

SENSITIVE
TOOTHPASTE
WITH FLUORIDE

NON-IRRITATING
SULFATE-FREE

HELPS REBUILD WEAKEND
TOOTH ENAMEL

Protects Against
Cavities

Freshens Breath

Non-Irritating
Formula

Gentle Mint

7oz (196g)

NON-IRRITATING
SULFATE-FREE

pH balanced

Fights
Cavities

Strengthens
Enamel

Closys®
Anticavity Fluoride Toothpaste

SENSITIVE TOOTHPASTE
WITH FLUORIDE

NON-IRRITATING SULFATE-FREE

HELPS REBUILD WEAKEND TOOTH ENAMEL

Protects Against Cavities

Freshens Breath

Non-Irritating Formula

Gentle Mint 7oz (196g)

7 carton

Closys®
Anticavity Fluoride Toothpaste

SULFATE-FREE

NEW LOOK!

A CLEANER MOUTH
A HEALTHIER YOU®

CLoSYS ®
Anticavity Fluoride Toothpaste

SENSITIVE
TOOTHPASTE
WITH FLUORIDE

NON-IRRITATING
SULFATE-FREE

HELPS REBUILD WEAKEND
TOOTH ENAMEL

Protects Against
Cavities

Freshens Breath

Non-Irritating
Formula

Gentle Mint

3.4oz (96g)

NON-IRRITATING
SULFATE-FREE

pH balanced

Fights
Cavities

Strengthens
Enamel

Closys®
Anticavity Fluoride Toothpaste

SENSITIVE TOOTHPASTE
WITH FLUORIDE

NON-IRRITATING SULFATE-FREE

HELPS REBUILD WEAKEND TOOTH ENAMEL

Protects Against Cavities

Freshens Breath

Non-Irritating Formula

Gentle Mint 3.4oz (96g)

3.4 carton

INDICATIONS & USAGE SECTION

LOINC: 34067-9Updated: 11/17/2021

USE:

Aids in the prevention of dental decay.

WARNINGS SECTION

LOINC: 34071-1Updated: 11/17/2021

WARNINGS:

OTC - KEEP OUT OF REACH OF CHILDREN SECTION

LOINC: 50565-1Updated: 10/20/2017

Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.

OTC - PURPOSE SECTION

LOINC: 55105-1Updated: 11/17/2021

PURPOSE:

Anticavity

OTC - ACTIVE INGREDIENT SECTION

LOINC: 55106-9Updated: 11/17/2021

ACTIVE INGREDIENT:

Sodium fluoride 0.24% (0.13% w/v fluoride ion)

DOSAGE & ADMINISTRATION SECTION

LOINC: 34068-7Updated: 10/20/2017

DIRECTIONS:

adults and children 2 years of age and older: brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor.

children under 6 years of age:

  • instruct in good brushing and rinsing habits (to minimize swallowing).
  • supervise children as necessary until capable of using without supervision.
  • do not swallow

children under 2 years of age:

consult a dentist or doctor

INACTIVE INGREDIENT SECTION

LOINC: 51727-6Updated: 11/17/2021

INACTIVE INGREDIENTS:

water, hydrated silica, stabilized chlorine dioxide, sarkosyl (coconut derived), disodium hydrogen phosphate, cellulose gum, titanium dioxide, peppermint oil, sodium dihydrogen phosphate, sucralose, menthol crystals

SPL UNCLASSIFIED SECTION

LOINC: 42229-5Updated: 11/17/2021

Use of stabilized chlorine dioxide is protected under U.S. & foregin patents- see CloSYS.com/patents

OTC - QUESTIONS SECTION

LOINC: 53413-1Updated: 11/17/2021

Questions or comments?

Call 1-800-643-3337

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CloSYS - FDA Drug Approval Details