MedPath

Otrexup

These highlights do not include all the information needed to use  safely and effectively. See full prescribing information for . OTREXUP (methotrexate) injection, for subcutaneous useInitial U.S. Approval: 1953

Approved
Approval ID

9ab8ce16-f7de-41d4-a4c8-1c742621b6d5

Product Type

HUMAN PRESCRIPTION DRUG LABEL

Effective Date

Dec 14, 2023

Manufacturers
FDA

Antares Pharma, Inc.

DUNS: 085369585

Products 8

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

methotrexate

PRODUCT DETAILS

NDC Product Code54436-022
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
METHOTREXATEActive
Quantity: 22.5 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB

methotrexate

PRODUCT DETAILS

NDC Product Code54436-012
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

METHOTREXATEActive
Quantity: 12.5 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB
SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

methotrexate

PRODUCT DETAILS

NDC Product Code54436-075
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
METHOTREXATEActive
Quantity: 7.5 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB

methotrexate

PRODUCT DETAILS

NDC Product Code54436-017
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

METHOTREXATEActive
Quantity: 17.5 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB
SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

methotrexate

PRODUCT DETAILS

NDC Product Code54436-010
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

METHOTREXATEActive
Quantity: 10 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB
SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

methotrexate

PRODUCT DETAILS

NDC Product Code54436-025
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

METHOTREXATEActive
Quantity: 25 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB
SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

methotrexate

PRODUCT DETAILS

NDC Product Code54436-020
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

METHOTREXATEActive
Quantity: 20 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB
WATERInactive
Code: 059QF0KO0R
Classification: IACT
SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT

methotrexate

PRODUCT DETAILS

NDC Product Code54436-015
Application NumberNDA204824
Marketing CategoryC73594
Route of AdministrationSUBCUTANEOUS
Effective DateNovember 21, 2017
Generic Namemethotrexate

INGREDIENTS (3)

METHOTREXATEActive
Quantity: 15 mg in 0.4 mL
Code: YL5FZ2Y5U1
Classification: ACTIB
SODIUM CHLORIDEInactive
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.