MedPath

Sugar Beet Pollen

Allergenic Extract

Approved
Approval ID

c7d383a6-94b8-4101-8a4c-fa7747a21468

Product Type

HUMAN PRESCRIPTION DRUG LABEL

Effective Date

Nov 13, 2009

Manufacturers
FDA

Antigen Laboratories, Inc.

DUNS: 030705628

Products 10

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Number Fourteen Grass Mixture

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0238
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Number Fourteen Grass Mixture
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (18)

POA COMPRESSA POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 50HCQ1NYV5
Classification: ACTIB
TYPHA LATIFOLIA POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 341PDX5PLM
Classification: ACTIB
BROMUS SECALINUS POLLENActive
Quantity: 0.0036 g in 1 mL
Code: Q4T1SJ3046
Classification: ACTIB
ZEA MAYS POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 74PD8J616H
Classification: ACTIB
SECALE CEREALE POLLENActive
Quantity: 0.0036 g in 1 mL
Code: I6KAZ8AO1O
Classification: ACTIB
PHALARIS ARUNDINACEA POLLENActive
Quantity: 0.0036 g in 1 mL
Code: FAY1Y90VJ9
Classification: ACTIB
HOLCUS LANATUS POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 70O1TP6H01
Classification: ACTIB
PASCOPYRUM SMITHII POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 6AU0ZD8T1O
Classification: ACTIB
BROMUS INERMIS POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 766QT72BK6
Classification: ACTIB
GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
TRITICUM AESTIVUM POLLENActive
Quantity: 0.0036 g in 1 mL
Code: F1KAH8374D
Classification: ACTIB
SORGHUM HALEPENSE POLLENActive
Quantity: 0.0036 g in 1 mL
Code: 577VA5B4HP
Classification: ACTIB
ELYMUS REPENS POLLENActive
Quantity: 0.0036 g in 1 mL
Code: ON2T85TA2O
Classification: ACTIB
ARRHENATHERUM ELATIUS POLLENActive
Quantity: 0.0036 g in 1 mL
Code: B55BD1QM4Q
Classification: ACTIB
SORGHUM BICOLOR SSP. DRUMMONDII POLLENActive
Quantity: 0.0036 g in 1 mL
Code: B43R30VP73
Classification: ACTIB

Bahia Grass

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0074
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Bahia Grass
Product Specifications
Route of AdministrationINTRADERMAL, SUBCUTANEOUS
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
PASPALUM NOTATUM POLLENActive
Quantity: 0.1 g in 1 mL
Code: V003SHB7VK
Classification: ACTIB
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

Bahia Grass

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0075
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Bahia Grass
Product Specifications
Route of AdministrationINTRADERMAL, SUBCUTANEOUS
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

PASPALUM NOTATUM POLLENActive
Quantity: 0.05 g in 1 mL
Code: V003SHB7VK
Classification: ACTIB
GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

Johnson Grass Pollen

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0276
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Johnson Grass Pollen
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
SORGHUM HALEPENSE POLLENActive
Quantity: 0.050 g in 1 mL
Code: 577VA5B4HP
Classification: ACTIB
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT

Sweet Clover Mixture

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0142
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Sweet Clover Mixture
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (6)

MELILOTUS OFFICINALIS POLLENActive
Quantity: 0.025 g in 1 mL
Code: UVC3Z60VTX
Classification: ACTIB
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
MELILOTUS ALBUS POLLENActive
Quantity: 0.025 g in 1 mL
Code: 9L67M8B78R
Classification: ACTIB

Western Wheatgrass

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0613
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Western Wheatgrass
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
PASCOPYRUM SMITHII POLLENActive
Quantity: 0.05 g in 1 mL
Code: 6AU0ZD8T1O
Classification: ACTIB
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

Sudan Grass

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0491
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Sudan Grass
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT
SORGHUM BICOLOR SSP. DRUMMONDII POLLENActive
Quantity: 0.05 g in 1 mL
Code: B43R30VP73
Classification: ACTIB

Cultivated Oat Pollen

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0346
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Cultivated Oat Pollen
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
AVENA SATIVA POLLENActive
Quantity: 0.05 g in 1 mL
Code: A7IKY24TR7
Classification: ACTIB
WATERInactive
Code: 059QF0KO0R
Classification: IACT

Velvet Grass

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0593
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Velvet Grass
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT
HOLCUS LANATUS POLLENActive
Quantity: 0.05 g in 1 mL
Code: 70O1TP6H01
Classification: ACTIB
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
WATERInactive
Code: 059QF0KO0R
Classification: IACT

Cultivated Wheat

Product Details

FDA regulatory identification and product classification information

FDA Identifiers
NDC Product Code49288-0608
Application NumberBLA102223
Product Classification
M
Marketing Category
C73585
G
Generic Name
Cultivated Wheat
Product Specifications
Route of AdministrationSUBCUTANEOUS, INTRADERMAL
Effective DateNovember 13, 2009
FDA Product Classification

INGREDIENTS (5)

SODIUM BICARBONATEInactive
Quantity: 0.0024 g in 1 mL
Code: 8MDF5V39QO
Classification: IACT
TRITICUM AESTIVUM POLLENActive
Quantity: 0.05 g in 1 mL
Code: F1KAH8374D
Classification: ACTIB
WATERInactive
Code: 059QF0KO0R
Classification: IACT
SODIUM CHLORIDEInactive
Quantity: 0.0095 g in 1 mL
Code: 451W47IQ8X
Classification: IACT
GLYCERINInactive
Quantity: 0.525 mL in 1 mL
Code: PDC6A3C0OX
Classification: IACT

Drug Labeling Information

BOXED WARNING SECTION

LOINC: 34066-1Updated: 11/13/2009

WARNINGS

ADVERSE REACTIONS SECTION

LOINC: 34084-4Updated: 11/13/2009

ADVERSE REACTIONS

Adverse reactions include, but are not limited to urticaria; itching; edema of extremities; respiratory wheezing or asthma; dyspnea; cyanosis; tachycardia; lacrimation; marked perspiration; flushing of face, neck or upper chest; mild persistent clearing of throat; hacking cough or persistent sneezing.

  1. Local Reactions

A mild burning immediately after injection is expected; this usually subsides in 10-20 seconds. Prolonged pain or pain radiating up arm is usually the result of intramuscular injection, making this injection route undesirable. Subcutaneous injection is the recommended route.

Small amounts of erythema and swelling at the site of injection are common. Reactions should not be considered significant unless they persist for at least 24 hours or exceed 50 mm in diameter.

Larger local reactions are not only uncomfortable, but indicate the possibility of a severe systemic reaction if dosage is increased. In such cases dosage should be reduced to the last level not causing reaction and maintained for two or three treatments before cautiously increasing.

Large, persistent local reactions or minor exacerbations of the patient’s allergic symptoms may be treated by local cold applications and/or use of oral antihistamines.

  1. Systemic Reactions

Systemic reactions range from mild exaggeration of patient’s allergic symptoms to anaphylactic reactions.14 Very sensitive patients may show a rapid response. It cannot be overemphasized that, under certain unpredictable combinations of circumstances, anaphylactic shock is always a possibility. Fatalities are rare but can occur.5 Other possible systemic reaction symptoms are fainting, pallor, bradycardia, hypotension, angioedema, cough, wheezing, conjunctivitis, rhinitis,and urticaria.13, 14

Careful attention to dosage and administration limit such reactions. Allergenic extracts are highly potent to sensitive individuals and OVERDOSE could result in anaphylactic symptoms. Therefore, it is imperative that physicians administering allergenic extracts understand and prepare for treatment of severe reactions. Refer to “OVERDOSAGE” section.

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