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FDA Approval

Orapred

FDA-approved pharmaceutical product with comprehensive regulatory information, manufacturing details, and complete labeling documentation.

FDA Approval Summary

Company
Effective Date
June 3, 2025
Labeling Type
Human Prescription Drug Label
Prednisolone(15 mg in 1 1)

Products3

Detailed information about drug products covered under this FDA approval, including NDC codes, dosage forms, ingredients, and administration routes.

Orapred ODT

Product Details

NDC Product Code
59212-701
Application Number
NDA021959
Marketing Category
NDA (C73594)
Route of Administration
ORAL
Effective Date
June 3, 2025
Code: IV021NXA9JClass: ACTIMQuantity: 15 mg in 1 1
CITRIC ACID MONOHYDRATEInactive
Code: 2968PHW8QPClass: IACT
SILICON DIOXIDEInactive
Code: ETJ7Z6XBU4Class: IACT
MANNITOLInactive
Code: 3OWL53L36AClass: IACT
CROSPOVIDONEInactive
Code: 68401960MKClass: IACT
HYPROMELLOSESInactive
Code: 3NXW29V3WOClass: IACT
CELLULOSE, MICROCRYSTALLINEInactive
Code: OP1R32D61UClass: IACT
DIMETHYLAMINOETHYL METHACRYLATE - BUTYL METHACRYLATE - METHYL METHACRYLATE COPOLYMERInactive
Code: 905HNO1SIHClass: IACT
SODIUM BICARBONATEInactive
Code: 8MDF5V39QOClass: IACT
SUCROSEInactive
Code: C151H8M554Class: IACT
SUCRALOSEInactive
Code: 96K6UQ3ZD4Class: IACT
MAGNESIUM STEARATEInactive
Code: 70097M6I30Class: IACT

Orapred ODT

Product Details

NDC Product Code
59212-700
Application Number
NDA021959
Marketing Category
NDA (C73594)
Route of Administration
ORAL
Effective Date
June 3, 2025
HYPROMELLOSESInactive
Code: 3NXW29V3WOClass: IACT
Code: IV021NXA9JClass: ACTIMQuantity: 10 mg in 1 1
CROSPOVIDONEInactive
Code: 68401960MKClass: IACT
SILICON DIOXIDEInactive
Code: ETJ7Z6XBU4Class: IACT
MAGNESIUM STEARATEInactive
Code: 70097M6I30Class: IACT
MANNITOLInactive
Code: 3OWL53L36AClass: IACT
CELLULOSE, MICROCRYSTALLINEInactive
Code: OP1R32D61UClass: IACT
SUCROSEInactive
Code: C151H8M554Class: IACT
SODIUM BICARBONATEInactive
Code: 8MDF5V39QOClass: IACT
DIMETHYLAMINOETHYL METHACRYLATE - BUTYL METHACRYLATE - METHYL METHACRYLATE COPOLYMERInactive
Code: 905HNO1SIHClass: IACT
SUCRALOSEInactive
Code: 96K6UQ3ZD4Class: IACT
CITRIC ACID MONOHYDRATEInactive
Code: 2968PHW8QPClass: IACT

Orapred ODT

Product Details

NDC Product Code
59212-702
Application Number
NDA021959
Marketing Category
NDA (C73594)
Route of Administration
ORAL
Effective Date
June 3, 2025
SILICON DIOXIDEInactive
Code: ETJ7Z6XBU4Class: IACT
CROSPOVIDONEInactive
Code: 68401960MKClass: IACT
Code: IV021NXA9JClass: ACTIMQuantity: 30 mg in 1 1
CITRIC ACID MONOHYDRATEInactive
Code: 2968PHW8QPClass: IACT
MAGNESIUM STEARATEInactive
Code: 70097M6I30Class: IACT
HYPROMELLOSESInactive
Code: 3NXW29V3WOClass: IACT
DIMETHYLAMINOETHYL METHACRYLATE - BUTYL METHACRYLATE - METHYL METHACRYLATE COPOLYMERInactive
Code: 905HNO1SIHClass: IACT
MANNITOLInactive
Code: 3OWL53L36AClass: IACT
CELLULOSE, MICROCRYSTALLINEInactive
Code: OP1R32D61UClass: IACT
SUCRALOSEInactive
Code: 96K6UQ3ZD4Class: IACT
SUCROSEInactive
Code: C151H8M554Class: IACT
SODIUM BICARBONATEInactive
Code: 8MDF5V39QOClass: IACT

Drug Labeling Information

Complete FDA-approved labeling information including indications, dosage, warnings, contraindications, and other essential prescribing details.

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

30 mg Carton

3

Rx only

NDC 59212-702-12

Contents: 2 cards containing 6 tablets
Grape Flavor
Orapred ODT®
(prednisolone sodium phosphate orally disintegrating tablets)
Equivalent to prednisolone 30mg


DESCRIPTION SECTION

11 DESCRIPTION

Orapred ODT (prednisolone sodium phosphate disintegrating tablets) is a sodium salt of the phosphoester of the glucocorticoid prednisolone. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.

Prednisolone sodium phosphate occurs as white or slightly yellow, friable granules or powder. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.

The chemical name of prednisolone sodium phosphate is pregna-1, 4-diene-3, 20-dione, 11, 17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11ß)-.
The empirical formula is C21H27Na2O8P; the molecular weight is 484.39. Its chemical structure is:

structure.jpg

Each orally disintegrating tablet also contains the following inactive ingredients: citric acid, colloidal silicon dioxide, crospovidone, grape flavor, hypromellose, magnesium stearate, mannitol, methacrylate copolymer, microcrystalline cellulose, sodium bicarbonate, sucralose, and sucrose.


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