NEURAN CAPSULE 300MG

CAPSULE

**DOSAGE AND ADMINISTRATION** Gabapentin is given orally with or without food. When in the judgment of the clinician, there is a need for dose reduction, discontinuation, or substitution with an alternative medication, this should be done gradually over a minimum of 1 week. **Epilepsy** _**Adults and pediatric patients older than 12 years of age:**_ In clinical trials, the effective dosing range was 900mg/day to 1800mg/day. Therapy may be initiated by administering 300mg three times a day on Day 1, or by titrating the dose (Table 1). Thereafter, the dose can be increased in three equally divided doses up to a maximum dose of 1800 mg/day. Doses up to 2400mg/day have been well tolerated in long-term open-label clinical studies. Doses up to 3600mg/day have been administered to a small number of patients for a relatively short duration, and have been well tolerated. The maximum time between doses in the three times a day schedule should not exceed 12 hours to prevent breakthrough convulsions.  _**Pediatric patients aged 3 to 12 years:**_ The starting dose should range from 10 to 15 mg/kg/day given in equally divided doses (three times a day), and the effective dose reached by upward titration over a period of approximately 3 days. The effective dose of gabapentin in pediatric patients aged 5 years and older is 25 to 35 mg/kg/day given in equally divided doses (three times a day). The effective dose in pediatric patients aged 3 to less than 5 years is 40 mg/kg/day given in equally divided doses (three times a day). Doses up to 50 mg/kg/day have been well tolerated in a long-term clinical study. The maximum time interval between doses should not exceed 12 hours. **Neuropathic pain in adults** The starting dose is 900 mg/day given in three equally divided doses, and increased if necessary, based on response, up to a maximum dose of 3600 mg/day. Therapy should be initiated by titrating the dose (Table 1). **Dose adjustment in impaired renal function in patients with neuropathic pain or epilepsy** Dose adjustment is recommended in patients with compromised renal function (Table 2) and/or in those undergoing hemodialysis.  **Dose adjustment in patients undergoing hemodialysis** For patients undergoing hemodialysis who have never received gabapentin, a loading dose of 300 mg to 400 mg is recommended, and then 200 mg to 300 mg of gabapentin following each 4 hours of hemodialysis.