GENOTROPIN FOR INJECTION 16 iu (5.3 mg) /ml

INJECTION, POWDER, FOR SOLUTION

**4.2 Posology and method of administration** The dosage and administration schedule should be individualized. Somatropin should be given subcutaneously and the injection site varied to prevent lipoatrophy. _Growth disturbance due to insufficient secretion of growth hormone in children:_ Generally, a dose of 0.07–0.10 international units/kg (0.025–0.035 mg/kg) body weight per day or 2.1–3.0 international units/m2 (0.7–1.0 mg/m2) body surface area per day is recommended. Even higher doses have been used. _Growth disturbance due to Turner syndrome:_ A dose of 0.14 international units/kg (0.045–0.050 mg/kg) body weight per day or 4.3 international units/m2 (1.4 mg/m2) body surface area per day is recommended.  _Growth hormone deficient adult patients:_ The recommended starting dose is 0.45 – 0.90 international units (0.15 – 0.30 mg) per day. The final dose should be individually titrated as needed with respect to age and gender. The daily maintenance dose seldom exceeds 4 international units (1.33 mg) per day. Women may require higher doses than men. This means that there is a risk that women, especially those on oral oestrogen replacement may be under-treated. As normal physiological growth hormone production decreases with age, dose requirements may be reduced. Clinical response, side effects, and determination of IGF-I in serum may be used as guidance for dose titration.