NEO-PENOTRAN PESSARY

INTEGA PTE LTD

INTEGA PTE LTD

Therapeutic

Prescription Only

SUPPOSITORY

**Posology and method of administration** _**Posology**_ Do not use without consulting a physician. If it is not advised otherwise by a physician; One ovule should be inserted at night and in the morning for 7 days. In recurrent cases, application of one ovule in the morning and one ovule at night for 14 days is recommended. It is not recommended that the administration of NEO-PENOTRAN® in the menstrual period because of the impaired efficacy of the product or facing some difficulties during administration. _**Method of administration**_ Only for intravaginal use. NEO-PENOTRAN® should be applied in lying position, high into the vagina. Not to be swallowed or applied by other routes. Additional information on special populations: _**Renal/Liver failure:**_ In renal failure, the half-life of metronidazole is not changed. In serious liver function failures, metronidazole clearance may be impaired. Metronidazole may increase encephalopathy symptoms due to increased plasma levels and therefore should be used carefully in hepatic encephalopathy patients. _**Paediatric population:**_ Not recommended for children. _**Geriatric population:**_ Same dose as for adults is administered in elderly over 65 years.