UltraTechneKow FM Generator

QT INSTRUMENTS (S) PTE LTD

QT INSTRUMENTS (S) PTE LTD

Therapeutic

Prescription Only

SOLUTION

**4.2 Posology and Method of Administration** Sodium pertechnetate (99mTc) is normally administered intravenously at activities which vary widely according to the clinical information required and the equipment employed. Other activities may be justifiable. It should be noted that in each country physicians should follow the Diagnostic Reference Levels and the rules set out by local law. Pre-treatment of patients with thyroid blocking agents or reducing agents may be necessary for certain indications. Recommended activities are as follows: _Adults and the elderly:_ - Thyroid scintigraphy: 18.5–80 MBq (0.5 – 2.2 mCi) Scintigraphy performed 20 minutes after intravenous injection. - Salivary gland scintigraphy: 40 MBq (1.1 mCi) Scintigraphy performed immediately after intravenous injection and at regular intervals up to 15 minutes. - Meckel's diverticulum scintigraphy: 400 MBq (10.8 mCi) Scintigraphy performed immediately after intravenous injection and at regular intervals up to 30 minutes. - Brain scintigraphy: 370–800 MBq (10 – 22 mCi) Rapid sequential images are taken immediately within the first minute after intravenous administration; static images 1 to 4 hours later. Thyroid and choroid plexus should be blocked to avoid non-specific 99mTc uptake. - Cardiac and vascular scintigraphy: 740–925 MBq (20 – 25 mCi) Red cells are labelled in-vivo or in-vitro by pretreating with a reducing agent. Dynamic images are taken in the first minute after intravenous administration, followed by regular images over 30 minutes. - Gastrointestinal bleeding: 740–925 MBq (20 – 25 mCi) Red cells are labelled in vivo or in vitro by pretreating with a reducing agent. Dynamic images are taken in the first minute after intravenous administration, followed by regular images at appropriate intervals for up to 24 hours. - Lacrimal dust scintigraphy: 2–4 MBq each eye (0.05 – 0.11 mCi) Drops are instilled into the eye and dynamic images are taken over 2 minutes, followed by static images at appropriate intervals over 20 minutes. _Children:_ The activity for administration to children may be calculated from the recommended range of adult activity and adjusted according to body weight or surface area. However, the Paediatric Task Group of EANM recommends that the activity to be administered to a child should be calculated from the body weight according to the following table: Fraction of adult dose:  In very young children (up to 1 year) a minimum dose of 20 MBq (10 MBq in thyroid scintigraphy) for direct administration or 80 MBq for red blood cell labelling is necessary in order to obtain images of sufficient quality.