AKYNZEO CAPSULES 300MG/0.5MG

JUNIPER BIOLOGICS PTE LTD

JUNIPER HEALTHCARE PTE LTD

Therapeutic

Prescription Only

CAPSULE, GELATIN COATED

**2 DOSAGE AND ADMINISTRATION** Administration One AKYNZEO capsule administered approximately 1 hour prior to the start of chemotherapy. Highly Emetogenic Chemotherapy, including Cisplatin Based Chemotherapy The recommended dosage in adults is one capsule of AKYNZEO administered approximately 1 hour prior to the start of chemotherapy with dexamethasone 12 mg administered orally 30 minutes prior to chemotherapy on day 1 and 8 mg orally once daily on days 2 to 4 _\[see Clinical Studies (14), Table 5)_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_ _\]_. \[From **14 CLINICAL STUDIES**\]  Anthracyclines and Cyclophosphamide Based Chemotherapy and Chemotherapy Not Considered Highly Emetogenic The recommended dosage in adults is one capsule of AKYNZEO approximately 1 hour prior to the start of chemotherapy with dexamethasone 12 mg administered orally 30 minutes prior to chemotherapy on day 1. Administration of dexamethasone on days 2 to 4 is not necessary _\[see Clinical Studies (14), Table 7_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_ _\]_. \[From **14 CLINICAL STUDIES**\]  AKYNZEO can be taken with or without food.