LIPEZ TABLET 10 MG

TABLET

**v. Recommended Dosage:** The patient should be on an appropriate lipid-lowering diet and should continue on this diet during treatment with LIPEZ. The recommended dose of LIPEZ is 10 mg once daily, used alone, or with a statin. LIPEZ can be administered at any time of the day, with or without food. **Patients with Renal Impairment** Monotherapy In patients with renal impairment, no dosage adjustment of LIPEZ is necessary (see IIIb-5 Characteristics in Patients \[Special Populations\] – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). Combination Therapy with Simvastatin In patients with mild renal impairment (estimated GFR ≥60 mL/min/1.73 m2), no dosage adjustment of LIPEZ or simvastatin is necessary. In patients with chronic kidney disease and estimated glomerular filtration rate <60 mL/min/1.73 m2, the dose of LIPEZ is 10 mg and the dose of simvastatin is 20 mg once a day in the evening. In such patients, the use of higher doses of simvastatin should be closely monitored. _Use in the Elderly_ No dosage adjustment is required for elderly patients. _Use in Pediatric Patients_ Children and adolescents ≥10 years: No dosage adjustment is required. Children <10 years: Treatment with LIPEZ is not recommended. _Use in Hepatic Impairment_ No dosage adjustment is required in patients with mild hepatic insufficiency (Child Pugh score 5 to 6). Treatment with ezetimibe is not recommended in patients with moderate (Child Pugh score 7 to 9) or severe (Child Pugh score >9) liver dysfunction. _Co-administration with bile acid sequestrants_ Dosing of LIPEZ should occur either ≥2 hours before or ≥4 hours after administration of a bile acid sequestrant.