MESNA STADA® CONCENTRATE SOLUTION FOR INJECTION 400MG/4ML

DCH AURIGA SINGAPORE

DCH AURIGA SINGAPORE

Therapeutic

Prescription Only

INJECTION, SOLUTION, CONCENTRATE

**Posology and method of administration** IV: Unless prescribed otherwise, MESNA Stada is normally administered intravenously to adults at a dose of 20% of the oxazaphosphorine dose at time zero (the time of administration of the oxazaphosphorine), and then at 4 and 8 hours.  Clinical experience with children has shown that it is beneficial in individual cases to give MESNA Stada at shorter intervals (e.g., every 3 hrs, total MESNA Stada dose = 60% of oxazaphosphorine dose). With very high-dose oxazaphosphorine cytostatic therapy (e.g., before bone marrow transplantation), the total MESNA Stada dose can be increased to between 120% and 160% of the oxazaphosphorine dose. It is recommended that after administration of 20% MESNA Stada (related to the total dose of oxazaphosphorine) at time 0, the remaining calculated dose should be given continuously IV over a period of 24 hrs with a perfusor. Alternatively, an intermittent bolus injection is possible: For adults 3 x 40% (at times 0, 4, 8 hrs) or 4 x 40% (at times 0, 3, 6, 9 hrs), respectively. For children due to more frequent micturition, the bolus injections should always be given in 3-hr intervals (e.g., 20% at times 0, 1, 3, 6, 9, 12 hrs). Instead of a bolus injection, short infusions of 15-min duration are possible. With a continuous infusion of ifosfamide (Holoxan), it has been shown to be of benefit to give MESNA Stada at time zero following the initial 20% bolus injection (start of infusion, time 0), followed by infusion to up to 100% of the ifosfamide dose, and to continue uroprotection for a further 6 to 12 hours after termination of the ifosfamide infusion.