DYMISTA NASAL SPRAY

SPRAY, METERED

**DOSAGE AND ADMINISTRATION** **Dosage** Adults, adolescents and children (6 years and older) One spray in each nostril twice daily (morning and evening). Children below 6 years DYMISTA® nasal spray is not recommended for use in children below 6 years of age as safety and efficacy has not been established in this age group. Elderly No dose adjustment is required in this population (see _Pharmacokinetics_ under _Special Populations_ – _Age_ and _PRECAUTIONS_ – _Use in the Elderly_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). Renal and hepatic impairment No dose adjustment is required in patients with renal impairment or mild to moderate hepatic impairment (see _Pharmacokinetics_ under _Special Populations_ – _Renal Impairment_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). Caution is required when treating patients with severe hepatic impairment (see _Pharmacokinetics_ under _Special Populations_ – _Hepatic Impairment_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). **Duration of treatment** DYMISTA® nasal spray is suitable for long-term use. There is no restriction regarding duration of use. **Method of Administration** DYMISTA® Nasal Spray is for administration by the nasal route only. Preparing the spray: Shake the bottle gently before each use for about 5 seconds. Then, remove the protective cap. Prior to first use, DYMISTA® nasal spray must be primed by pressing down and releasing the pump 6 times until a fine mist appears. If DYMISTA® nasal spray has not been used for more than 7 days, reprime by pressing down and releasing the pump a number of times until a fine mist is produced. Do not prick the nozzle in case spray is not obtained. Clean the actuator with water. Using the spray: After blowing the nose, spray the suspension once into each nostril keeping the head tilted downward. After each use, wipe the spray tip and replace the protective cap.