KANARB TABLET 60MG

TABLET

**Recommended Dosage** Adult Hypertension The recommended initial dose of Kanarb® Tablets is 60 mg once daily with or without food. If blood pressure is not adequately controlled at 60 mg, the dosage of Kanarb® Tablets may be increased to 120 mg once daily. Whenever possible, it is recommended that Kanarb® Tablets be taken at the same time during the day (e.g., morning). The blood pressure lowering effect of Kanarb® Tablets is generally attained within 2 weeks, and maximal reduction is after 8 to 12 weeks of treatment. Geriatric Use No initial dosage adjustment is required for elderly patients (age ≤ 70 years). Renal Impairment No initial dosage adjustment is required for patients with mild to moderate renal impairment (creatinine clearance 30–80 mL/min). For severe renal impairment (creatinine clearance < 30 mL/min), the recommended initial dose is 30 mg once daily and the dose should not exceed 60 mg. Hepatic Impairment No initial dosage adjustment is required for patients with mild hepatic impairment. Kanarb® Tablets is not recommended to patients with moderate to severe hepatic impairment. Pediatric Use The efficacy and safety of Kanarb® Tablets has not been established in patients 18 years or younger. Intravascular Volume-Depleted Patients (e.g., Patients receiving high doses of diuretics) For patients whose intravascular volume is depleted, at risk for symptomatic hypotension, the initial dose of 30 mg once daily is recommended.