PULIN INJECTION 10 mg/2 ml

YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD

YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD

Therapeutic

Prescription Only

INJECTION

**Posology and method of administration:** The solution can be administered intravenously (IV) or intramuscularly (IM). **Adults** The recommended single dose is 10 mg, repeated up to three times daily. Prevention of PONV: a single dose of 10 mg is recommended. The maximum recommended daily dose is 30 mg or 0.5 mg/kg body weight. The injectable treatment duration should be as short as possible and transfer to oral or rectal treatment should be made as soon as possible. Treatment durations beyond 12 weeks should be avoided unless the therapeutic benefit is judged to outweigh the risk to the patient. _Elderly_ In elderly patients a dose reduction should be considered, based on renal and hepatic function and overall frailty. _Renal impairment_ In patients with severe renal impairment (creatinine clearance ≤15 mL/min), the daily dose should be reduced by 75%. In patients with moderate to severe renal impairment (creatinine clearance 15–60 mL/min), the dose should be reduced by 50%. _Hepatic impairment_ In patients with severe hepatic impairment, the dose should be reduced by 50%. **Children (aged 1–18 years)** The recommended dose is 0.10 to 0.15 mg/kg body weight, repeated up to three times daily by the intravenous route. The recommended maximum dose in 24 hours is 0.5 mg/kg body weight. Dosing table  The injectable treatment duration should be as short as possible. The recommended maximum treatment duration is 48 hours for treatment of established post-operative nausea and vomiting (PONV). Metoclopramide is contraindicated in children aged less than 1 year. ( _See “Contraindications”_) Due to the potential risk of severe cardiovascular reactions including cardiac arrest, the solutions for injection are restricted to be used only when appropriate resuscitation equipment is available. ( _See “Undesirable effects, Cardiovascular disorders”_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_) **Method of administration** IV doses should be administered as a slow bolus (at least over 3 minutes). A minimum interval of 6 hours between two administrations is to be respected, even in case of vomiting or rejection of dose ( _See “Special warnings”_ – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_).