OMEPRO OMEPRAZOLE POWDER FOR SOLUTION FOR INJECTION 40MG/VIAL

HETERO SINGAPORE PTE. LTD.

HETERO SINGAPORE PTE. LTD.

Therapeutic

Prescription Only

INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION

**DOSAGE AND ADMINISTRATION** **Dosage** Omeprazole 40mg as once-daily intravenous application is recommended in those incidental cases where oral therapy is inappropriate and pronounced acidity inhibition is essential. The mean reduction of acid production in the stomach during 24hours is circa 90%. With Zollinger-Ellison patients, the recommended initial dosage is 60mg omeprazole per day. For a 60mg dose, an additional half (5ml) of reconstituted solution should be given as an intravenous injection. Any unused solution should be discarded. Higher dosage can be necessary, and the dosage of more than 60mg per day, the administration of the daily dosage should be spread out the day. A one-week treatment is usually sufficient. **Administration** Omeprazole sodium for injection is for intravenous administration only and must not be given by any other route. **Direction for reconstitution** Omeprazole sodium for injection should only be dissolved in water for injection. After reconstitution outside validated aseptic conditions, use within 4 hours of preparation and any unused portion should be discarded. The duration of administration should be over 5 minutes. **Use in the elderly** Dosage adjustment is not necessary. **Use in children** There is limited experience of use in children. Therefore, omeprazole injection is not recommended in children. **Impaired renal function** Dose adjustment is not required in patients with impaired renal function. **Impaired hepatic function** As half-life is increased in patients with impaired hepatic function, the dose requires adjustment and a daily dose of 10–20 mg may be sufficient.