Igantibe 200 IU/ml

INJECTION

**Posology** Slow injection by the i.m. route. If large doses (> 5 ml) are required, it is advisable to administer them in divided doses at different sites. - Post-exposure prophylaxis: After exposure to material containing or with a high risk of containing HBs-antigen in a non-vaccinated person, the usual practice is to inject 12 international units to 20 international units per kg of body weight as soon as possible, preferably within 24 hours and initiate hepatitis B vaccination. After exposure in a vaccinated person who is known not to have responded to the primary vaccine series, give either a single dose (12 – 20 international units/kg) of human antihepatitis B immunoglobulin and a dose of hepatitis B vaccine as soon as possible or two doses of human antihepatitis B immunoglobulin (one given in the first 24 hours and the second 1 month later). If the exposed person has already been vaccinated and the response is unknown, test for anti-HBs antibodies. If the response is inadequate (< 10 milli-international units/ml) give one dose of human antihepatitis B immunoglobulin immediately and a booster of vaccine. If the response is adequate, there is no necessity of treatment. If facilities are not available for testing, immediately give one dose of human antihepatitis B immunoglobulin. - Prophylaxis in neonates of HBsAg positive mother: 40 international units/kg body weight within 12 hours of birth and the first dose of hepatitis B vaccine. The administration of hepatitis B vaccine should be at a different site of the body with separate lymphatic drainage. HBsAg positive persons should not be given antihepatitis B immunoglobulin as no prophylactic effect will be expected.