SODIUM BICARBONATE INTRAVENOUS INFUSION 8.4% w/v

INJECTION

**Dosage** The quantity of Sodium Bicarbonate Intravenous Infusion BP to be infused is determined by the blood gas values and is calculated according to the following formulae: mL of 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP = negative base excess x kg b.w. x 0.3 (The factor 0.3 corresponds to the proportion of the extracellular fluid in relation to total body fluid). The maximum daily dose is determined according to the correction requirements. Correction of metabolic acidosis should not be affected too rapidly. It is advisable to start administering only half of the calculated dose and adjust further doses according to the actual results of blood gas analysis. Blind buffer therapy is not advisable. It should only be performed in life-threatening situations. _Flow rate_ Up to 1.5 mmol of sodium bicarbonate per kg body weight per hour, corresponding to 1.5 ml of 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP/kg bw/h. _Route of administration_ Strictly intravenously! 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP has an osmolarity of about 2000 mOsm/l and, when infused undiluted, it should be administered via central venous catheter, preferably inserted into the vena cava.