DIPEPTIVEN INFUSION

INJECTION

**Posology and method of administration** For central venous infusion after addition to a compatible infusion solution. Solutions of mixtures with an osmolarity above 800 mosmol/l should be infused by the central venous route. _**Adults**_ Dosage depends on the severity of the catabolic state and on amino acid requirement. A maximum daily dosage of 2 g amino acids/kg body weight should not be exceeded in parenteral nutrition. The supply of alanine and glutamine via Dipeptiven® should be taken into consideration in the calculation. The proportion of the amino acid supplied through Dipeptiven should not exceed approx. 30% of the total amino acid supply. _**Daily dose**_ 1.5 – 2.5 ml of Dipeptiven per kg body weight (equivalent to 0.3 – 0.5 g N(2)-L-alanyl-L-glutamine per kg body weight). This equates to 100 to 175 ml Dipeptiven for a patient of 70 kg body weight. Maximum daily dose: 2.5 ml equivalent to 0.5 g N(2)-L-alanyl-L-glutamine of Dipeptiven® per kg body weight. The maximum daily dose of 0.5 g N(2)-L-alanyl-L-glutamine per kg body weight should be administered in combination with a compatible amino acid solution providing at least 1.0 g amino acids per kg body weight and day. This results in a daily dosage of at least 1.5 g amino acids per kg body weight. The following adjustments are examples for the supply with Dipeptiven and other amino acids through the carrier solution: Amino acid requirement 1.2 g/kg body weight per day: 0.8 g amino acids + 0.4 g N(2)-L-alanyl-L-glutamine per kg body weight. Amino acid requirement 1.5 g/kg body weight per day: 1.0 g Amino acids + 0.5 g N(2)-L-alanyl-L-glutamine per kg body weight. Amino acid requirement 2 g/kg body weight per day: 1.5 g amino acids + 0.5 g N(2)-L-alanyl-L-glutamine per kg body weight. The rate of infusion depends on that of the carrier solution and should not exceed 0.1 g amino acids/kg body weight per hour. Dipeptiven® is an infusion solution concentrate which is not designed for direct administration. It should be mixed with a compatible amino acid carrier solution or an amino acid containing infusion regimen prior to administration. One volume part Dipeptiven® is to be mixed with at least 5 volume parts carrier solution (e.g. 100 ml Dipeptiven® \+ at least 500 ml amino acid solution). 3.5 % of the active ingredient should be the maximum concentration during therapy. The duration of use should not exceed 3 weeks. _**Children**_ Safety and efficacy in children have not been established.